Thyrotropin-releasing hormone excites submucous neurons in guinea-pig ileum.
Thyrotropin-releasing hormone excites submucous neurons in guinea-pig ileum.
复制标题
促甲状腺激素释放激素兴奋豚鼠回肠中的粘膜下神经元。
DOI：
10.1016/0014-2999(91)90843-f
复制
发表时间：
1991
影响因子：
5
通讯作者：
Wood,JD
中科院分区：
文献类型：
--
作者：
Zafirov,DH;Cooke,HJ;Wood,JD
用细胞内电生理方法观察促甲状腺素释放激素（TRH）对豚鼠回肠粘膜下神经元的作用。TRH在S/ 1型和AH/ 2型神经元中引起兴奋反应。这些反应包括缓慢激活膜去极化，增强兴奋性和钾电导降低导致的输入电阻增加。结果表明TRH具有神经调节/神经递质功能。
Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.