Developing a Biomarker Feedback Intervention to Motivate Smoking Cessation During Pregnancy: Phase II MAW Study.
Developing a Biomarker Feedback Intervention to Motivate Smoking Cessation During Pregnancy: Phase II MAW Study.
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制定生物标志物反馈干预措施以促进怀孕期间戒烟：第二阶段 MAW 研究。
DOI：
10.1093/ntr/ntw330
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Patten,ChristiA
中科院分区：
文献类型：
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作者：
Koller,KathrynR;Flanagan,ChristieA;Day,GretchenE;Thomas,TimothyK;Smith,ChristinaA;Wolfe,AbbieW;Meade,Crystal;Hughes,ChristineA;Hiratsuka,VanessaY;Murphy,NeilJ;Patten,ChristiA
阿拉斯加原住民（AN）妇女怀孕期间吸烟的流行率是非阿拉斯加原住民妇女的三倍多。在这项定性研究中，我们征求输入AN妇女和其他人，以确定如何最好地呈现从早期的研究结果表明，母亲吸烟（可替宁）和新生儿暴露于烟草特异性致癌物4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁醇（NNAL）之间的生物标志物之间的强相关性，以激励case.MethodsWe开发了一本小册子，将广义生物标志物的信息。通过对孕妇和产后AN妇女及其伴侣/家庭成员进行深入的个人访谈，我们探讨了这些信息的适用性和可接受性。参与早期相关性研究的产后妇女还获得了其个体生物标志物结果。我们评估是否被提出一般或个人的生物标志物信息将激励停止使用content analysis.ResultsWe进行了39次采访：16名孕妇，12名产后妇女，和11个合作伙伴/家庭成员。总体而言，参与者同意生物标志物信息是新的，但可以理解。产后妇女分享，学习他们的个人结果激励他们想要戒烟或减少吸烟，而孕妇表示，广义相关信息是在激励case.ConclusionGeneralized信息帮助不大，胎儿接触致癌物可能是更有效的激励孕妇戒烟时，结合个人可替宁testing. Implications使用本研究的反馈，我们改进并正在评估一种干预措施，该措施结合了I期和可替宁试验的广义相关信息，以确定其在促使AN孕妇戒烟方面的有效性。
IntroductionThe prevalence of smoking during pregnancy for Alaska Native (AN) women is more than triple that of non-Native Alaska women. In this qualitative study, we solicited input from AN women and others to determine how best to present findings from an earlier study demonstrating a strong correlation between biomarkers for maternal smoking (cotinine) and neonatal exposure to a tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) to motivate cessation.MethodsWe developed a brochure incorporating generalized biomarker information. Using in-depth individual interviews with pregnant and postpartum AN women and partners/family members, we explored applicability and acceptability of the information. Postpartum women, who had participated in the earlier correlation study, additionally received their individual biomarker results. We assessed whether being presented general or individual biomarker information would motivate cessation using content analysis.ResultsWe conducted 39 interviews: 16 pregnant women, 12 postpartum women, and 11 partners/family members. Overall, participants agreed the biomarker information was new, but understandable as presented. Postpartum women shared that learning their personal results inspired them to want to quit or cut back smoking while pregnant women indicated the generalized correlation information was less helpful in motivating cessation.ConclusionGeneralized information about fetal exposure to carcinogens may be more effective in motivating pregnant women to quit smoking when combined with individual cotinine testing.ImplicationsUsing feedback from this study, we refined and are currently evaluating an intervention incorporating generalized correlation information from Phase I and cotinine testing to determine its effectiveness in motivating smoking cessation among pregnant AN women.