The impact of epilepsy on subjective health status.
The impact of epilepsy on subjective health status.
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DOI：
10.1007/s11910-003-0014-0
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发表时间：
2003-07-01
影响因子：
5.6
通讯作者：
Gilliam, Frank
中科院分区：
文献类型：
--
作者：
Gilliam, Frank
癫痫是一种慢性疾病，对个人健康的许多方面都有复杂的影响。可靠有效地评估主观健康状况的方法的最新进展使我们对这些不同影响的理解取得了重大进展，并为指导治疗和未来研究提供了证据。包括癫痫患者生活质量、患者偏好和残疾的研究表明，复发性癫痫发作对主观健康状况许多方面的不良影响程度与糖尿病和活动性心血管疾病一样大。癫痫手术后以患者为导向的综合结局研究表明，在广泛的功能和福祉领域有积极的治疗效果。虽然很少有癫痫药物试验包括健康结果工具，但现有研究表明，癫痫发作减少50%以上与生活质量改善有关。药物不良反应和抑郁似乎与癫痫患者的主观健康状况有很强的相关性，与癫痫发作频率无关。
Epilepsy is a chronic disorder that has complex effects on many aspects of personal health. Recent advances in the methods to reliably and validly assess subjective health status have allowed major advances in our understanding of these diverse effects, and have also provided evidence to guide treatment and future research. Studies that have included measures of quality of life, patient preferences, and disability in epilepsy have shown that the magnitude of the adverse effects of recurrent seizures on many aspects of subjective health status is as large as that seen with diabetes mellitus and active cardiovascular disease. Studies of patient-oriented, comprehensive outcomes after epilepsy surgery indicate positive treatment effects in broad areas of function and well-being. Although few trials of epilepsy drugs have included health outcome instruments, available studies suggest that greater than 50% seizure reduction is associated with improved quality of life. Adverse medication effects and depression appear to have a strong association with subjective health status in epilepsy, independent of seizure frequency.