Synthesis, Relaxivity, and T1 Relaxation Enhancement of Binuclear Gadolinium(iii) Complexes Based on DTPA or EDTA and Long-Chain Alkyl Esters of l-Lysine
Synthesis, Relaxivity, and T1 Relaxation Enhancement of Binuclear Gadolinium(iii) Complexes Based on DTPA or EDTA and Long-Chain Alkyl Esters of l-Lysine
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DOI：
10.1071/ch06214
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发表时间：
2007-04
影响因子：
1.1
通讯作者：
Kai-chao Yu;Yousef Hamdan;Fuxian Wan;Yinxia Li;Kaixun Huang;Jin-lan Zhou
中科院分区：
文献类型：
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作者：
Kai-chao Yu;Yousef Hamdan;Fuxian Wan;Yinxia Li;Kaixun Huang;Jin-lan Zhou
以L-赖氨酸长链烷基酯为原料，分别与二乙烯三胺五乙酸单酐或乙二胺四乙酸单酐进行酰胺化反应，合成了8种新型的二氨基酯配体。用GdCl_3中心点6 H（2）O处理这些配体得到相应的二聚Gd（III）配合物。所有配体和配合物均通过H-1 NMR、FT-IR和元素分析进行了表征。测量了纵向弛豫时间（T-1），这些二聚体Gd（III）配合物的弛豫率值（R-1）均高于Magnivest（Gd-DTPA）。选择其中一种在DTPA系列中具有最高弛豫率的复合物来测试急性毒性和T-1加权成像。结果发现，这种二聚Gd（III）络合物没有急性毒性，并且与Magnivest相比，在大鼠肝组织中提供高度增强的MRI信号并增加意向时间。
Eight novel diamino-ester ligands were synthesized by amidation reaction of long-chain alkyl esters of L-lysine with diethylenetriamine pentaacetic acid monoanhydride or ethylenediamine tetraacetic acid monoanhydride. The corresponding dimeric Gd(III) complexes were obtained by treating these ligands with GdCl3 center dot 6H(2)O. All ligands and complexes were characterized by H-1 NMR, FT-IR, and elemental analysis. The longitudinal relaxation time (T-1) was measured, and all relaxivity values (R-1) of these dimeric Gd(III) complexes are higher than that of Magnivest (Gd-DTPA). One of these complexes, possessing the highest relaxivity in the DTPA series, was chosen to test the acute toxicity and T-1-weighted imaging. It was found that this dimeric Gd(III) complex exhibits no acute toxicity, and offers highly enhanced MRI signal and increases intention time in the rat liver tissue compared to Magnivest.