Demographic and Clinical Characteristics and Risk Factors for Infantile Hemangioma A Chinese Case-Control Study
Demographic and Clinical Characteristics and Risk Factors for Infantile Hemangioma A Chinese Case-Control Study
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中国病例对照研究婴儿血管瘤的人口统计学和临床特征及危险因素
DOI：
10.1001/archdermatol.2011.122
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发表时间：
2011-09-01
影响因子：
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通讯作者：
Xie, Hongfu
中科院分区：
文献类型：
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作者：
Li, Jie;Chen, Xiang;Xie, Hongfu
目的：研究中国婴儿血管瘤的人口统计学和临床特征;更详细地了解发展这种疾病的危险因素;并确定与并发症相关的临床特征、相关风险和系统治疗的必要性。设计：一项前瞻性纳入1832名血管瘤儿童和1832名年龄、性别、地区、地点：中南地区的两家大型医院，患者：1832例血管瘤患儿，主要指标：人口统计学和临床表现，并与以往血管瘤研究的数据进行比较。预测并发症和/或治疗的临床因素和婴儿血管瘤的潜在危险因素进行了分析logistic regression.Results：我们的研究患者的临床特征是不同的，从其他种族/民族组的形态学亚型，并发症，并发症和预测因素和/或口服皮质类固醇治疗方面的先前的研究报告。调整后，血管瘤的显著危险因素包括母亲教育水平较低（比值比[OR]，0.61; 95%置信区间[CI]，0.57-0.66），母亲从事体力劳动（OR，1.29; 95% CI，1.12-1.48），多胎妊娠（OR，1.20; 95% CI，1.05-1.36），围受孕期母亲用药情况（OR，2.08; 95%CI，1.88-2.31），以及血管瘤阳性家族史（OR，1.55; 95%CI，1.40-1.72）。除了在血管瘤的危险因素方面产生了一些新的发现外，目前的研究还表明，中国血管瘤的临床特征在流行病学上与西方有些不同。
Objectives: To study the demographic and clinical features of infantile hemangioma in China; to learn in more detail the risk factors for developing this disease; and to identify clinical characteristics associated with complications, associated risks, and the need for systemic treatment.Design: A case-control study of 1832 prospectively enrolled children with hemangiomas and 1832 controls matched for age, sex, region, and hospital attending the dermatology department between 2005 and 2008.Setting: Two large hospitals in central south China.Patients: A total of 1832 children with hemangiomas.Main Outcome Measures: Demographic and clinical presentations were summarized and compared with data from previous studies of hemangiomas. Predictive clinical factors for complications and/or treatment and potential risk factors for infantile hemangioma were analyzed by logistic regression.Results: The clinical features of our study patients were different from those of other race/ethnicity groups reported by previous studies with regard to the morphologic subtypes, complications, and predictors for complications and/or oral corticosteroid treatment. After adjustment, significant risk factors for hemangiomas included lower level of maternal education (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.57-0.66), mother engaged in manual labor (OR, 1.29; 95% CI, 1.12-1.48), multiple gestation (OR, 1.20; 95% CI, 1.05-1.36), maternal medication use during the periconceptional period(OR, 2.08; 95% CI, 1.88-2.31), and a positive family history of hemangiomas (OR, 1.55; 95% CI, 1.40-1.72).Conclusion: Besides yielding several new findings with respect to risk factors for hemangiomas, the current study also suggests that the Chinese clinical features of hemangiomas are somewhat different epidemiologically from those in the West.