Suppressive effects of ethanolic extracts from propolis and its main botanical origin on dioxin toxicity
Suppressive effects of ethanolic extracts from propolis and its main botanical origin on dioxin toxicity
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DOI：
10.1021/jf058111a
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发表时间：
2005-12-28
影响因子：
6.1
通讯作者：
Pastore, GM
中科院分区：
文献类型：
--
作者：
Park, YK;Fukuda, I;Pastore, GM
抑制效果的乙醇提取物制备的12组和它的主要植物来源（Bacchads dracunculifolia的叶芽）的芳烃受体（AhR）的转化，二恶英毒性的初始行动，进行了研究。结果表明，在无细胞体系和Hepa-1c 1c 7细胞中，树脂对AhR转化的抑制作用相对高于其植物来源的树脂。当测量化学成分的组成时，与具有相同特征的植物来源相比，甘草含有略高量的黄酮苷元。此外，抗自由基活性，黄酮类化合物的典型的生物活性之一，也略高于其植物来源。这些结果表明，不仅枸杞，而且其植物来源含有大量的黄酮苷元，它们都是有用的膳食来源的黄酮类化合物的效力，以防止二恶英毒性。
Suppressive effects of ethanolic extracts prepared from propolis group 12 and its main botanical origin (leaf bud of Bacchads dracunculifolia) on transformation of the aryl hydrocarbon receptor (AhR), the initial action of dioxin toxicity, were investigated. It was found that suppressive effects of propolis on AhR transformation were relatively higher than those of resins of its botanical origin in cell-free system and in Hepa-1c1c7 cells. When the composition of chemical ingredients was measured, propolis contained slightly higher amounts of flavonoid aglycones as compared with its botanical origin with the same characteristics. Moreover, antiradical activity, one of the typical biological activities of flavonoids, in propolis was also slightly higher than that in its botanical origin. These results indicate that not only propolis but also its botanical origin contains high amounts of flavonoid aglycones and that both of them are useful dietary sources for flavonoids with a potency to prevent dioxin toxicity.