TESTOSTERONE ADMINISTRATION INHIBITS GONADOTROPIN-SECRETION BY AN EFFECT DIRECTLY ON THE HUMAN PITUITARY
TESTOSTERONE ADMINISTRATION INHIBITS GONADOTROPIN-SECRETION BY AN EFFECT DIRECTLY ON THE HUMAN PITUITARY
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DOI：
10.1210/jcem-68-2-397
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发表时间：
1989-02-01
影响因子：
5.8
通讯作者：
BREMNER, WJ
中科院分区：
文献类型：
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作者：
SHECKTER, CB;MATSUMOTO, AM;BREMNER, WJ
睾酮(T)和给药会减慢男性的黄体生成素脉冲频率，可能是通过对下丘脑GnRH脉冲发生器的影响，但它也可能对垂体有直接作用。为了确定T是否确实通过直接作用于垂体而影响促性腺激素的分泌，我们研究了T对gnrh刺激的促性腺激素分泌的影响。对6例促性腺功能减退症患者给予生理剂量的GnRH治疗。G / 2h， sc通过自动给药泵)，持续6周。一旦他们的促性腺激素水平正常，除了GnRH外，这些男性还接受了超生理剂量的T酸盐（200毫克，每日一次，持续8周）。然后在最后8周的时间里，他们只接受GnRH。在三个研究期结束时，每10分钟进行一次血液采样，持续8小时。T治疗将平均血清LH水平抑制到GnRH单独治疗时的50%左右[18 .+-]。2 . (.+-. se) vs. （.+-. se）2 .mu.g / L;P < 0.05]并将血清FSH平均水平抑制至GnRH单独作用时的30%左右(39。6对128 .+-。28 .mu.g / L;P < 0.05)。停止T治疗8周后，继续使用GnRH，血清LH和FSH水平与第一期GnRH治疗结束时相似。在给药期间，LH对GnRH的平均反应降低（17.1 +-）。3 .mu。g/L)，与单纯GnRH作用初期相比(31。4 .mu.g / L;P < 0.05)。单独使用GnRH后，血清T和雌二醇水平在低正常范围内。2 nmol/L和105。，分别为17 pmol/L)，并在给药8周后增加到略高于正常成人范围(36。5 nmol/L和264 .+-。49 pmol/L)。这些结果表明，T和/或其代谢物通过一种与gnrh无关的机制抑制促黄体生成素和促卵泡刺激素的分泌，可能直接作用于人类脑垂体。
Testosterone (T) and administration slows LH pulse frequency in man, presumably by an effect on the hypothalamic GnRH pulse generator, but it also may have a direct action on the pituitary. To determine if T does indeed after gonadotropin secretion by acting directly on the pituitary, we studied the effect of T on GnRH-stimulated gonadotropin secretion. Six men with hypogonadotropic hypogonadism were treated with physiological doses of GnRH (5 .mu.g every 2 h, sc by automatic infusion pump) for 6 weeks. Once their gonadotrophin levels were normal, the men received a supraphysiological dosage of T enanthate (200 mg, im, weekly for 8 weeks) in addition to GnRH. They then received GnRH alone for a final 8-week period. Blood sampling was performed every 10 min for 8 h at the end of each of the three study periods. T administration suppressed the mean serum LH level to about 50% of the value during GnRH alone [18 .+-. 2 (.+-.SE) vs. 37 .+-. 2 .mu.g/L; P < 0.05] and suppressed the mean serum FSH level to about 30% of the value during GnRH alone (39 .+-. 6 vs. 128 .+-. 28 .mu.g/L; P < 0.05). Eight weeks after stopping T, while continuing GnRH alone, serum LH and FSH levels were similar to those at the end of the first period of GnRH administration. The mean LH response to GnRH was reducing during T administration (17 .+-. 3 .mu.g/L) compared to that during the initial period of GnRH alone (31 .+-. 4 .mu.g/L; P < 0.05). Serum T and estradiol levels were in the low normal range after GnRH alone before T administration (11 .+-. 2 nmol/L and 105 .+-. 17 pmol/L, respectively) and increased to just above the normal adult ranges after 8 weeks of T administration (36 .+-. 5 nmol/L and 264 .+-. 49 pmol/L, respectively). These results demonstrate that T and/or its metabolites inhibit LH and FSH secretion by a GnRH-independent mechanism, probably directly on the pituitary gland, in man.