Event-related potentials (ERPs) to hemifield presentations of emotional stimuli: differences between depressed patients and healthy adults in P3 amplitude and asymmetry
Event-related potentials (ERPs) to hemifield presentations of emotional stimuli: differences between depressed patients and healthy adults in P3 amplitude and asymmetry
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DOI：
10.1016/s0167-8760(00)00078-7
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发表时间：
2000-06-01
影响因子：
3
通讯作者：
Quitkin, FM
中科院分区：
文献类型：
--
作者：
Kayser, J;Bruder, GE;Quitkin, FM
抑郁症可能涉及右顶颞叶皮层功能障碍，该区域在感知情感刺激时被激活。为了进一步检验这一假设，我们以先前证明健康成年人顶叶上的情感刺激会产生 ERP 不对称的范式来测量事件相关脑电位 (ERP)。将患有皮肤病的患者在手术治疗之前（阴性）或之后（中性）面部区域出现紊乱或愈合的照片短暂暴露于左半视野或右半视野 250 毫秒。通过 30 个电极记录了 30 名未接受药物治疗的单相抑郁症患者和 16 名健康成年人（均为右利手）的 ERP。主成分分析提取了与之前为此任务报告的独特 ERP 成分密切对应的因素（N1、N2、P3 早期、P3 晚期、慢波）。在 P3 的早期和晚期发现了情绪内容的显着影响，即负面刺激的幅度比中性刺激的幅度增强。对照组受试者在 P3 后期（峰值潜伏期 460 毫秒）表现出明显的半球情绪处理不对称，其中右侧顶叶区域的情绪内容影响最大。与对照受试者形成鲜明对比的是，抑郁症患者与任一半球的中性刺激相比，在阴性刺激下并未表现出 P3 晚期的增加，并且 P3 晚期振幅比对照受试者更小。然而，患者对阴性刺激的早期 P3（峰值潜伏期 330 毫秒）确实比中性刺激表现得更大。结果表明，抑郁症患者的早期辨别力完整，但后期对情感内容的评估异常，这可能是由于对感知和评估情绪刺激不可或缺的右顶叶区域的选择性抑制所致。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Depression may involve dysfunction of right parietotemporal cortex, a region activated during perception of affective stimuli. To further test this hypothesis, event-related brain potentials (ERPs) were measured in a paradigm previously shown to produce ERP asymmetries to affective stimuli over parietal sites in healthy adults. Pictures of patients with dermatological diseases showing disordered or healed facial areas before (negative) or after (neutral) surgical treatment were briefly exposed for 250 ms to either the left or right hemifield. ERPs of 30 unmedicated, unipolar depressed patients and 16 healthy adults, all right-handed, were recorded from 30 electrodes. A principal components analysis extracted factors which closely corresponded to distinctive ERP components previously reported for this task (N1, N2, early P3, late P3, slow wave). Significant effects of emotional content, i.e. enhanced amplitudes to negative than neutral stimuli, were found for early and late P3. Control subjects showed significant hemispheric asymmetries of emotional processing for late P3 (peak latency 460 ms), with the largest emotional content effects over the right parietal region. In striking contrast to control subjects, depressed patients did not show an increase in late P3 for negative compared to neutral stimuli over either hemisphere and had smaller late P3 amplitude than control subjects. Patients did, however, show larger early P3 (peak latency 330 ms) to negative than neutral stimuli. Results suggest intact early discrimination but abnormal late appraisal of affective content in depression, which may arise from selective inhibition of right parietal regions integral for perceiving and evaluating emotional stimuli. (C) 2000 Elsevier Science B.V. All rights reserved.