Skeletal muscle mitochondria in health and disease
Skeletal muscle mitochondria in health and disease
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DOI：
10.1016/j.ceca.2021.102357
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发表时间：
2021-02-05
期刊：
影响因子：
4
通讯作者：
Mammucari, Cristina
中科院分区：
文献类型：
--
作者：
De Mario, Agnese;Gherardi, Gaia;Mammucari, Cristina
线粒体活动保证了氧化肌纤维的能量供应，以维持耐力工作负荷。线粒体稳态的维持是通过控制裂变和融合过程以及线粒体自噬去除异常细胞器来保证的。许多疾病是由于线粒体功能失调或以线粒体功能失调为特征，线粒体动力学或周转的改变本身就会引发肌病。在这篇综述中，我们将解决线粒体动力学，周转和代谢在骨骼肌中的作用，无论是在健康和疾病。
Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission and fusion processes and by the mitophagic removal of aberrant organelles. Many diseases are due to or characterized by dysfunctional mitochondria, and altered mitochondrial dynamics or turnover trigger myopathy per se. In this review, we will tackle the role of mitochondrial dynamics, turnover and metabolism in skeletal muscle, both in health and disease.