COVID-19 Vaccination and Hospitalization Among Persons Living With Diagnosed HIV in New York State.
COVID-19 Vaccination and Hospitalization Among Persons Living With Diagnosed HIV in New York State.
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DOI：
10.1097/qai.0000000000003177
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发表时间：
2023-06-01
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与未确诊艾滋病毒的人相比，确诊艾滋病毒感染者（PLWDH）的COVID-19诊断率更高，COVID-19相关结果更差。对于PLWDH，尚未充分研究COVID-19疫苗接种状态与严重COVID-19结果可能性的交叉点。纽约州（NYS）。我们匹配了HIV监测、免疫接种和住院数据库，以比较B.1.617.2（Delta）和B.1.1.529（Omicron）主导期间PLWDH中COVID-19疫苗接种和COVID-19相关住院情况。截至2022年3月4日，101，205名艾滋病病毒携带者中有69，137人（68%）接受了COVID-19的全面疫苗接种或加强免疫。与病毒未受抑制（77%对44%）或没有护理证据（74%对33%）的PLWDH相比，病毒受抑制或护理的PLWDH更经常接受完全疫苗接种或加强免疫。总体住院率较低的病毒抑制PLWDH。在Delta优势期间，与未接受治疗的人相比，有任何疫苗接种史的PLWDH的住院率较低;在Omicron优势期间，只有加强PLWDH才是这种情况。纽约州约有28%（28，255）的PLWDH仍未接种COVID-19疫苗，这一比例约为纽约州成年人口的两倍。与非西班牙裔白色人相比，有色人种的PLWDH更经常未接种疫苗，病毒未受抑制和没有艾滋病毒相关护理证据的人也是如此，这可能会扩大COVID-19相关结果的现有差异。接种疫苗可以预防PLWDH的COVID-19相关住院;然而，完全接种疫苗和未接种疫苗的PLWDH之间住院率的差异小于所有纽约人之间的差异。
Persons living with diagnosed HIV (PLWDH) have higher COVID-19 diagnoses rates and poorer COVID-19–related outcomes than persons living without diagnosed HIV. The intersection of COVID-19 vaccination status and likelihood of severe COVID-19 outcomes has not been fully investigated for PLWDH. New York State (NYS). We matched HIV surveillance, immunization, and hospitalization databases to compare COVID-19 vaccination and COVID-19–related hospitalizations among PLWDH during B.1.617.2 (Delta) and B.1.1.529 (Omicron) predominance. Through March 4, 2022, 69,137 of the 101,205 (68%) PLWDH were fully vaccinated or boosted for COVID-19. PLWDH who were virally suppressed or in care were more often to be fully vaccinated or boosted compared with PLWDH who were not virally suppressed (77% vs. 44%) or without evidence of care (74% vs. 33%). Overall hospitalization rates were lower among virally suppressed PLWDH. During Delta predominance, PLWDH with any vaccination history who were in care had lower hospitalization rates compared with those not in care; during Omicron predominance, this was the case only for boosted PLWDH. Approximately 28% (28,255) of PLWDH in NYS remained unvaccinated for COVID-19, a rate roughly double of that observed in the overall adult NYS population. PLWDH of color were more often than non-Hispanic White persons to be unvaccinated, as were the virally unsuppressed and those without evidence of HIV-related care, threatening to expand existing disparities in COVID-19–related outcomes. Vaccination was protective against COVID-19–related hospitalizations for PLWDH; however, differences in hospitalization rates between fully vaccinated and unvaccinated PLWDH were smaller than those among all New Yorkers.