The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults
The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults
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DOI：
10.1038/sj.ijo.0802693
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发表时间：
2004-09-01
影响因子：
4.9
通讯作者：
Rodgers, A
中科院分区：
文献类型：
--
作者：
Mhurchu, CN;Poppitt, SD;Rodgers, A
背景：壳聚糖是一种脱乙酰化的甲壳素，是一种广泛使用的膳食补充剂，旨在通过胃肠道脂肪结合来降低体重和血脂。目的：评价壳聚糖对超重和肥胖成年人减肥的疗效。设计和设置：一项为期24周的随机、双盲、安慰剂对照试验，于2001年11月至2002年12月在奥克兰大学进行。体重指数35.5（5.1）kg/m2;平均年龄48（12）岁。干预：参与者被随机分配接受3g壳聚糖/天（n = 125）或安慰剂（n = 125）。所有参与者都接受了标准化的饮食和生活方式减肥建议。通过胶囊计数监测依从性。主要观察指标：主要观察指标是体重的变化。次要结果包括体重指数、腰围、体脂百分比、血压、血脂、血糖、脂溶性维生素、粪便脂肪和健康相关的生活质量的变化。-0.4（0.2）kg（减少0.4%）vs +0.2（0.2）kg（增加0.2%），P = 0.03），但影响较小。循环总胆固醇、低密度脂蛋白胆固醇和血糖也有类似的微小变化（P < 0.01）。有没有任何其他测量outcomes.CONCLUSION组之间的显着差异：在这个24周的试验中，壳聚糖治疗没有导致临床显着的体重减轻与安慰剂相比。
CONTEXT: Chitosan, a deacetylated chitin, is a widely available dietary supplement purported to decrease body weight and serum lipids through gastrointestinal fat binding. Although evaluated in a number of trials, its efficacy remains in dispute.OBJECTIVE: To evaluate the efficacy of chitosan for weight loss in overweight and obese adults.DESIGN AND SETTING: A 24-week randomised, double-blind, placebo-controlled trial, conducted at the University of Auckland between November 2001 and December 2002.PARTICIPANTS: A total of 250 participants (82% women; mean (s.d.) body mass index, 35.5 (5.1) kg/m(2); mean age, 48 (12) y).INTERVENTIONS: Participants were randomly assigned to receive 3 g chitosan/day (n = 125) or placebo (n = 125). All participants received standardised dietary and lifestyle advice for weight loss. Adherence was monitored by capsule counts.MAIN OUTCOME MEASURES: The primary outcome measure was change in body weight. Secondary outcomes included changes in body mass index, waist circumference, body fat percentage, blood pressure, serum lipids, plasma glucose, fat-soluble vitamins, faecal fat, and health-related quality of life.RESULTS: In an intention-to-treat analysis with the last observation carried forward, the chitosan group lost more body weight than the placebo group (mean (s.e.), -0.4 (0.2) kg (0.4% loss) vs +0.2 (0.2) kg (0.2% gain), P = 0.03) during the 24-week intervention, but effects were small. Similar small changes occurred in circulating total and LDL cholesterol, and glucose (P < 0.01). There were no significant differences between groups for any of the other measured outcomes.CONCLUSION: In this 24-week trial, chitosan treatment did not result in a clinically significant loss of body weight compared with placebo.