Cardiac side population cells: moving toward the center stage in cardiac regeneration.
Cardiac side population cells: moving toward the center stage in cardiac regeneration.
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DOI：
10.1161/circresaha.111.243014
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发表时间：
2012-05-11
影响因子：
20.1
通讯作者：
Liao R
中科院分区：
文献类型：
--
作者：
Unno K;Jain M;Liao R
在过去的十年中，在动物模型和人类中进行的大量工作已经确定了成人心脏中存在祖细胞，能够形成心肌的分化，并可能在正常发育和疾病期间促进心肌细胞的更新。在已鉴定的心脏祖细胞中，有一个独特的亚群，称为“侧群”（SP）祖细胞，它们通过atp结合盒转运体外排DNA结合染料的独特能力被分离出来。本文综述了有关CSP细胞的分离、表征和功能相关性的文献。我们回顾了成人心肌中心肌SP （CSP）细胞的初步发现，以及它们在心肌损伤后的功能性心肌分化和心脏再生中的作用。最后，我们讨论了在了解心脏SP细胞增殖和分化的分子调节因子方面的最新进展，以及实现有效心脏再生目标所需的可能的未来研究领域。
Over the past decade, extensive work in animal models and humans has identified the presence of progenitor cells within the adult heart, capable of cardiomyogenic differentiation and likely contributors to cardiomyocyte turnover during normal development and disease. Among the identified cardiac progenitor cells, there is a distinct subpopulation, termed “side population” (SP) progenitor cells, which are isolated by their unique ability to efflux DNA binding dyes through ATP-binding cassette transporter. This review highlights the literature on the isolation, characterization and functional relevance of CSP cells. We review the initial discovery of cardiac SP (CSP) cells in adult myocardium, as well as their capacity for functional cardiomyogenic differentiation and role in cardiac regeneration following myocardial injury. Finally, we discuss recent advances in understanding the molecular regulators of cardiac SP cell proliferation and differentiation, as well as likely future areas of investigation required to realize the goal of effective cardiac regeneration.