METABOLISM OF TISSUES EXCISED FROM THYROXINE-INJECTED RATS
METABOLISM OF TISSUES EXCISED FROM THYROXINE-INJECTED RATS
复制标题
DOI：
10.1152/ajplegacy.1952.170.1.81
复制
发表时间：
1952-01-01
影响因子：
--
通讯作者：
KLITGAARD, HM
中科院分区：
文献类型：
--
作者：
BARKER, SB;KLITGAARD, HM
自1905年首次实验测量甲状腺机能亢进对组织代谢过程的影响以来，越来越多的证据表明，这些动物表现出的低代谢或高代谢是由于其组织代谢的相应改变。由于最近对大量文献进行了详细调查(1)，因此在此仅作总结。除了少数例外，肝脏、肾脏、骨骼肌和心脏的变化情况非常一致。以大脑为例，来自6个实验室（2-7）的报告一致认为，甲状腺改变的任何代谢影响都小于50%，而其他3个小组（8-10）声称增加了代谢影响，在一个例子中，在脱水甲状腺喂养后增加了4倍。三份报告（2,5，II）声称甲状腺素注射对脾脏qo2没有影响，尽管Anselmino等人（II）也发现对肾脏没有影响。两个报告睾丸的实验室结果截然相反，一个（12）发现增加，另一个(5)没有变化。当然，虽然本文不能完全解决这种差异，但值得注意的是，我们的研究结果有力地支持了脑、脾或睾丸对注射甲状腺素没有反应的观点。除了Gordon和Heming (s)外，工人们主要关注的是甲状腺机能亢进，通过持续给药来维持。随着肌肉、肝脏和肾脏等组织的总体变化的确定，现在更仔细地检查整个动物和组织反应之间的定量关系变得很重要。此外，甲状腺机能亢进的早期变化应该更多地揭示甲状腺素的内在作用，因为它正在产生显著的代谢反应。
Ever SINCE the first experiments in 1905 measuring the effect of hyper-thyroidism on metabolic processes in tissues, evidence has been accumulating that the hypo-or hypermetabolism exhibited by such animals is due to corresponding alterations in the metabolism of their tissues. Since the extensive literature has recently been surveyed in detail (I), it will merely be summarized here. With few exceptions, agreement is excellent on liver, kidney, skeletal muscle and heart as being altered. In the case of brain, reports from six laboratories (2-7) concur that any metabolic effect of thyroid alterations is less than IO per cent, while three other groups (8-10) claim increases, in one instance as great as fourfold after desiccated thyroid feeding. Three reports (2, 5, II) claimed noeffectsof thyroxineinjection on spleen qo2, although Anselmino et aZ.(II) also found no effect on kidney. The two laboratories reporting on testis were diametrically opposed, one (12) finding an increase and the other no alteration (5). Although the present paper cannot, of course, entirely resolve such discrepancies, it will be noted that our findings lend strong support to there being no response on the part of brain, spleen or testis to injection of thyroxine.With the exception of Gordon and Heming (s), workers have been concerned primarily with a hyperthyroidism well maintained by continued administration of hormone. With the gross changes in such tissues as muscle, liver and kidney e. stablished, it now becomes important to sxamine quantitative relationships between whole animal and tissue responses more carefully. In addition, the early changes leading to a well-established hyperthyroidism should reveal more about the intimate effects of thyroxine as it is producing its marked metabolic responses.