[Expression and role of IL-18 in chronic rhinosinusitis].
[Expression and role of IL-18 in chronic rhinosinusitis].
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DOI：
10.13201/j.issn.1001-1781.2018.07.005
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发表时间：
2018-04-01
影响因子：
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通讯作者：
Liu, S X
中科院分区：
文献类型：
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作者：
Liu, R W;Du, J T;Liu, S X
目的：探讨白细胞介素-18（IL-18）在慢性鼻窦炎（CRS）不同临床表型及CRS伴鼻息肉（CRSwNP）不同亚型中的表达及意义。结果：CRSwNP分为IL-5 + NP组（12例）和IL-5-NP组（24例），IL-5+NP组（12例）和IL-5-NP组（24例），IL-5+NP组（12例）和IL-5-NP组（24例）分别检测CRSwNP组织中IL-5的表达，IL-18 mRNA和蛋白的表达水平。CRSsNP、IL-5+NP和IL-5-NP组IL-18 mRNA和蛋白表达均高于对照组（P
Objective:To study the expression and role of interleukin-18 (IL-18) in different clinical phenotypes of chronic rhinosinusitis(CRS)and in different subtypes of CRS with nasal polyps (CRSwNP).Method:During nasal endoscopic surgery, inferior turbinates were obtained from 13 patients with nasal septum deviation (control group),uncinate processes were obtained from 10 patients with chronic rhinosinusitis without nasal polyps (CRSsNP) and nasal polyp tissues were obtained from 36 patients with CRSwNP, respectively. IL-5 expression in CRSwNP was detected by ELISA, and the expression of IL-18 mRNA and protein in different subtypes of CRS were assessed by real-time PCR, ELISA and immunohistochemistr.Result:CRSwNP was divided into 12 cases of IL-5 positive nasal polyps (IL-5+NP)group and 24 cases of IL-5 negative nasal polyps (IL-5-NP)group. The expression of IL-18 mRNA and protein in all CRSsNP,IL-5+NP and IL-5-NP groups were higher than that in control group (P