Visual mismatch negativity in the detection of facial emotions in patients with panic disorder
Visual mismatch negativity in the detection of facial emotions in patients with panic disorder
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DOI：
10.1097/wnr.0b013e32835eb63a
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发表时间：
2013-03
期刊：
影响因子：
1.7
通讯作者：
Di Tang;Jing Xu;Yi Chang;Ya Zheng;Na Shi;Xiao-mei Pang;Bing-Wei Zhang
中科院分区：
文献类型：
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作者：
Di Tang;Jing Xu;Yi Chang;Ya Zheng;Na Shi;Xiao-mei Pang;Bing-Wei Zhang
惊恐障碍是一种高度流行的精神疾病，其特征是突然和反复的惊恐发作。对惊恐障碍患者的研究发现，惊恐障碍患者的面部表情策略处理功能异常，惊恐相关刺激的自动处理功能异常。然而，惊恐障碍患者面部情绪的自动加工是否正常尚不清楚。视觉失配否定性（vMMN）反映了变化检测的自动处理。我们记录了与表情相关的vMMN，比较了12例惊恐障碍患者和17例年龄匹配和教育匹配的对照组对图式面部情绪（消极和积极）的自动检测。在晚时间窗（220 ~ 330 ms），惊恐障碍患者消极和积极两种情绪的vMMN波幅均显著降低（P=0.02）。这一发现表明，惊恐障碍患者自动识别面部情绪的能力受损。这是第一个关于表达相关vMMN用于惊恐障碍患者的报告。
Panic disorder is a highly prevalent mental disease characterized by sudden and recurrent panic attacks. Studies on patients with panic disorder have found dysfunctional strategic processing of facial expressions and abnormal automatic processing of panic-related stimuli. However, whether the automatic processing of facial emotions in patients with panic disorder is normal is unknown. Visual mismatch negativity (vMMN) reflects automatic processing of change detection. We recorded expression-related vMMN to compare the automatic detection of schematic facial emotions (negative and positive) of 12 patients with panic disorder and 17 age-matched and education-matched controls. During the late time window (220–330 ms), the vMMN amplitudes for two emotions (negative and positive) were significantly decreased in patients with panic disorder (P=0.02). This finding implies that the ability to automatically detect facial emotions is impaired in patients with panic disorder. This is the first report on expression-related vMMN being used with patients with panic disorder.