Alendronate-related oral mucosa ulcerations
Alendronate-related oral mucosa ulcerations
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DOI：
10.1034/j.1600-0714.2000.291006.x
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发表时间：
2000-11-01
影响因子：
3.3
通讯作者：
Bagan-Sebastian, JV
中科院分区：
文献类型：
--
作者：
Gonzalez-Moles, MA;Bagan-Sebastian, JV
阿仑膦酸钠广泛用于治疗骨质疏松症和其他骨疾病。尽管它被认为是一种耐受性良好的药物，但有大量报告称其对上呼吸消化道粘膜产生不良影响，其中食管炎是最常见的并发症。对正确用药的严格规定表明，这些副作用很可能是上呼吸消化道直接刺激机制的结果。我们介绍了两例因服用阿仑膦酸钠而出现广泛性腭溃疡的患者的临床病例。我们讨论与溃疡产生有关的可能机制和一些感兴趣的临床因素。
Alendronate is widely used in the treatment of osteoporosis and other bone diseases. Although it is considered a well-tolerated drug, there are numerous reports of adverse effects on the mucosa in the upper aerodigestive tract, with oesophagitis as the most common complication. The strict regulations for the proper administration of the drug indicate that these side effects might well be the result of a direct, irritant mechanism on the upper aerodigestive tract. We present two clinical cases of patients who developed extensive palatal ulcers as a result of taking alendronate. We discuss possible mechanisms implicated in the production of the ulcers and some clinical factors of interest.