TWO CASES OF ERUPTIVE PYODERMA GANGRENOSUM ASSOCIATED WITH COCAINE USE
TWO CASES OF ERUPTIVE PYODERMA GANGRENOSUM ASSOCIATED WITH COCAINE USE
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DOI：
10.1016/s0001-7310(08)76179-9
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发表时间：
2008-11-01
影响因子：
3.2
通讯作者：
Alegre de Miquel, V.
中科院分区：
文献类型：
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作者：
Roche, E.;Martinez-Menchon, T.;Alegre de Miquel, V.
我们提出了2例30岁和37岁的常规可卡因使用者，他们出现了一种皮肤状况，具有相同的表现和相似的临床过程。病变最初表现为背部的皮疹，然后扩散到身体的其他部位。它们包括疼痛的炎性结节，发展成脓肿和向外生长的溃疡。基部有肉芽肿，边缘不规则。组织病理学研究的结果与坏疽性脓皮病的临床诊断相一致，并且其他检查排除了潜在疾病。在常规治疗多次失败后，患者在中断可卡因消费后对英夫利昔单抗迅速产生反应。坏疽性脓皮病和可卡因使用之间的联系很明显，因为当他们再次开始使用毒品时，他们都在同一时间经历了临床复发。
We present the cases of 2 regular cocaine users aged 30 and 37 years who developed a cutaneous condition with an identical presentation and a similar clinical course. The lesions first appeared as eruptions on the back and then spread to other parts of the body. They consisted of painful inflammatory nodules that developed into abscesses and ulcers that grew outwards. They had a granulomatous base and irregular violaceous edges. The results of histopathologic studies were compatible with the clinical diagnosis of pyoderma gangrenosum, and additional tests ruled out underlying diseases. After several therapeutic failures with usual treatments, the patients responded quickly to infliximab after interrupting their cocaine consumption. The association between pyoderma gangrenosum and cocaine use was clear as both suffered clinical relapses at the same time as they started using the drug again.