History of febrile illness and variation in semen quality
History of febrile illness and variation in semen quality
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DOI：
10.1093/humrep/deg412
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发表时间：
2003-10-01
影响因子：
6.1
通讯作者：
Skakkebæk, NE
中科院分区：
文献类型：
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作者：
Carlsen, E;Andersson, AM;Skakkebæk, NE
背景：本研究的目的是分析发热病史对精液质量的影响。方法：在1998年3月至1999年6月的16个月期间，在丹麦的哥本哈根，对27名健康男性（中位年龄24.4岁）进行了每月精液样本和每日发热事件发生率的随访。分析精液样本的精液量、精子浓度、不动精子百分比和形态正常精子百分比。研究结果：在减数分裂期间发热后精子浓度显著降低32.6%（95%置信区间-49.9; -9.2），在精子发生的减数分裂后期发热后精子浓度显著降低35.0%（-50.5; -14.6）。精子发生过程中，发热使形态正常的精子减少7.4%（-11.6; -3.0），不活动精子增加20.4%（6.0; 36.8）。男性经历发烧的天数显著影响了他们的精液参数。因此，减数分裂和精子发生期间的发热分别使精子浓度降低7.1%（-12.9; -0.9）和8.5%（-13.6; -3.0）/天。在精子发生过程中，发热每天，形态正常的精子百分比下降1.6%（-2.5; -0.6），不动精子百分比增加4.5%（1.7; 7.3）。然而，个体对发热的反应存在很大差异。结论：精液样本中的精子浓度、形态和活力会受到精子发生减数分裂后期（精子发生）发热事件的不利影响。精子浓度也受到不利影响，在减数分裂期间的发热，而在精子发生过程中的其他时间点发热似乎没有显着影响这些精子参数。副作用似乎取决于发烧的天数。
BACKGROUND: The purpose of this study was to analyse the effect of a history of febrile illness on semen quality. METHODS: Twenty-seven healthy men (median age 24.4 years) were followed with monthly semen samples and a daily record of the occurrence of experienced febrile episodes over a 16 month period between March 1998 and June 1999 in Copenhagen, Denmark. Semen samples were analysed for semen volume, sperm concentration, percentage immotile sperm and percentage morphologically normal sperm. RESULTS: Sperm concentration significantly decreased by 32.6% (95% confidence interval -49.9; -9.2) following fever during meiosis and by 35.0% (-50.5; -14.6) following fever during the postmeiotic period of spermatogenesis (spermiogenesis). The percentage of morphologically normal sperm was decreased by 7.4% (-11.6; -3.0) and the percentage of immotile sperm was increased by 20.4% (6.0; 36.8) by fever during spermiogenesis. The number of days the men experienced fever significantly affected their semen parameters. Thus fever during meiosis and spermiogenesis reduced sperm concentration with respectively 7.1% (-12.9; -0.9) and 8.5% (-13.6; -3.0) per day of fever. The percentage of morphologically normal sperm decreased 1.6% (-2.5; -0.6) and the percentage of immotile sperm increased 4.5% (1.7; 7.3) per day of fever during spermiogenesis. There was, however, a large variation in the individual response to fever. CONCLUSIONS: Sperm concentration, morphology and motility in a semen sample are adversely affected by a febrile episode during the postmeiotic period of spermatogenesis (spermiogenesis). Sperm concentration was also adversely affected by fever during the period of meiosis, whereas fever at other time points during spermatogenesis did not seem to significantly affect these sperm parameters. The adverse effect seemed to be dependent upon the number of days with fever.