STANDARDIZED PRECISION RADIOTHERAPY IN CHOROIDAL METASTASES
STANDARDIZED PRECISION RADIOTHERAPY IN CHOROIDAL METASTASES
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DOI：
10.3109/02841869409098378
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发表时间：
1994-01-01
期刊：
影响因子：
3.1
通讯作者：
WILKING, N
中科院分区：
文献类型：
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作者：
NYLEN, U;KOCK, E;WILKING, N
眼脉络膜转移是常见于播散性恶性肿瘤患者。我们在这里报告的结果，使用精确的放射治疗技术描述的Schipper等。治疗14 17例（21只眼）的症状，从这样的转移。使用光束定义准直器，并在治疗眼单独固定的情况下提供横向视野。使用了不同的分数和剂量。早期效应（BED 3）的生物学有效剂量为47 - 90戈伊，晚期效应（BED 10）为28 - 59戈伊。14眼（82%）转移灶完全消退。所有患者视力稳定或提高，无需局部手术。3例患者出现放射性视网膜病变体征，但仅1例患者的视功能受损。使用这种标准化技术，不需要个体化剂量计划，辐射性白内障的风险最小化，并避免了干眼症。
Metastases in the choroid of the eye are frequent in patients with disseminated malignancy. We here report the results using the precision radiotherapy technique described by Schipper et al. to treat 14 of 17 consecutive patients (21 eyes) with symptoms from such metastases. A beam defining collimator was used and a lateral field was given with the treated eye individually fixed. Varying fractionations and doses were used. The biologically effective dose for early effects (BED3) was 47 to 90 Gy and for late effects (BED10) 28 to 59 Gy. In 14 eyes (82%) the metastases regressed completely. The visual acuity was stabilized or improved in all patients and none needed local surgery. Three patients developed signs of radiation retinopathy, but only in one case the visual function was compromized. With this standardized technique no individualized dose planning was needed, the risk of radiation cataract was minimized and a dry eye avoided.