Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy
Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy
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DOI：
10.1080/10715760500539147
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发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Koletzko, B
中科院分区：
文献类型：
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作者：
Shoji, H;Franke, C;Koletzko, B
二十二碳六烯酸（二十二碳六烯酸，DHA）是妊娠期对细胞膜有较高需求的不可缺少的成分。DHA的补充被认为会增强氧化应激，因为脂质过氧化的可能性增加。我们估计了两组孕妇的氧化应激水平，这些孕妇从妊娠20周到分娩时每天服用所需维生素（n = 23）或不服用（n = 23） 500毫克DHA和150毫克二十碳五烯酸（EPA）。8-羟基-2'-脱氧鸟苷（8-OHdG） （DNA氧化损伤的标志物）和丙二醛（MDA）（脂质过氧化的标志物）的尿排泄在20周、30周和分娩时被测量。在整个研究期间，两组的尿丙二醛排泄量保持不变。分娩时尿8-OHdG排泄量显著高于20周和30周（p < 0.05），但三个时间点组间差异无统计学意义。两组患者血浆α -生育酚水平无差异。我们得出结论，在研究条件下，孕妇每天补充500mg DHA和150mg EPA并没有增加脂质过氧化或氧化性DNA损伤。
Docosahexaenoic acid (DHA) is an indispensable component of cell membranes with high requirements during pregnancy. DHA supplementation is thought to enhance oxidative stress because of increased likelihood of lipid peroxidation. We estimated the oxidative stress levels in two groups of pregnant women who received daily supply of required vitamins with (n = 23) or without (n = 23) 500 mg of DHA and 150mg of eicosapentaenoic acid (EPA) from 20 weeks of gestation to the time of delivery. Urinary excretions of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage and of malondialdehyde (MDA), a marker of lipid peroxidation, were measured at 20, 30 weeks and at the time of delivery. Urinary MDA excretion remained unchanged throughout the study period in both groups. Urinary 8-OHdG excretion at delivery was significantly higher than at 20 and 30 weeks (p < 0.05), but there were no group differences at the three time points. There were no differences between the two groups in plasma alpha-tocopherol levels. We conclude that under the conditions studied, a daily supplementation of 500mg DHA and 150mg EPA with vitamins to pregnant women did not enhance lipid peroxidation or oxidative DNA damage.