Sialic Acids and Their Influence on Human NK Cell Function.

Sialic Acids and Their Influence on Human NK Cell Function.
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唾液酸及其对人类 NK 细胞功能的影响。

DOI:
10.3390/cells10020263
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发表时间:
2021-01-29
期刊:
影响因子:
6
通讯作者:
Kaufmann T
Kaufmann T
中科院分区:
生物学2区
文献类型:
--
作者:
Rosenstock P;Kaufmann T

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唾液酸是具有九碳骨架的糖,存在于人体所有细胞的表面,包括免疫细胞及其靶细胞,具有多种功能。自然杀伤 (NK) 细胞是先天免疫系统的细胞,能够杀死病毒感染的细胞和肿瘤细胞。唾液酸可以通过多种方式影响 NK 细胞与潜在靶标的相互作用。不同的 NK 细胞受体可以结合唾液酸,导致 NK 细胞抑制或激活。此外,NK细胞表面有唾液酸,可以调节受体的丰度和活性。本综述重点关注 NK 细胞及其靶细胞上的唾液酸如何参与 NK 细胞功能。
Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing virus-infected and tumor cells. Sialic acids can influence the interaction of NK cells with potential targets in several ways. Different NK cell receptors can bind sialic acids, leading to NK cell inhibition or activation. Moreover, NK cells have sialic acids on their surface, which can regulate receptor abundance and activity. This review is focused on how sialic acids on NK cells and their target cells are involved in NK cell function.
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