Sialic Acids and Their Influence on Human NK Cell Function.
Sialic Acids and Their Influence on Human NK Cell Function.
复制标题
唾液酸及其对人类 NK 细胞功能的影响。
DOI:
10.3390/cells10020263
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发表时间:
2021-01-29
期刊:
影响因子:
6
通讯作者:
Kaufmann T
中科院分区:
文献类型:
--
作者:
Rosenstock P;Kaufmann T
Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing virus-infected and tumor cells. Sialic acids can influence the interaction of NK cells with potential targets in several ways. Different NK cell receptors can bind sialic acids, leading to NK cell inhibition or activation. Moreover, NK cells have sialic acids on their surface, which can regulate receptor abundance and activity. This review is focused on how sialic acids on NK cells and their target cells are involved in NK cell function.
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