SENSORIMOTOR CORTICAL PROJECTIONS TO THE PRIMATE CUNEATE NUCLEUS
SENSORIMOTOR CORTICAL PROJECTIONS TO THE PRIMATE CUNEATE NUCLEUS
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DOI：
10.1002/cne.902400209
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
WHITSEL, BL
中科院分区：
文献类型：
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作者：
CHEEMA, S;RUSTIONI, A;WHITSEL, BL
组织的皮质醇途径进行了研究，在猴子通过使用顺行和逆行轴突运输的辣根过氧化物酶（HRP）或麦胚凝集素结合辣根过氧化物酶（WGA-HRP）。将任一示踪剂注射到中央前皮质（以区域4为中心）导致被盖区（位于楔状核的腹外侧，特别是在奥贝斯尾侧的水平）出现大量顺行标记。另一方面，涉及区域3b、1和2的相同示踪剂的注射主要在核心内引起顺行标记（pars rotunda of Ferraro and Barrera，“35，Arch. Neurol. 33：262-75）的楔核。顺行标记在楔束核的吻侧部分也很明显，尤其是在涉及区域1和2的注射后。注射主要局限于3b区，导致顺行标记优先在楔状核的核心。将HRP或WGA-HRP注入延髓背侧后，逆行标记的神经元出现在中央前回和中央后回，但其位置取决于注射部位的部位和范围。当示踪剂扩散到下面的被盖区，许多逆行标记的神经元出现在中央前运动皮层，主要是在4区，虽然他们中的一些也发生在6区。随着注射量的减少，大部分标记的神经元主要集中在楔状核内，大多数标记的神经元出现在中央后回，其中1区和2区的数量最多; 3b区的小神经元数量较少，最好用WGA-HRP显示; 3a区含有最少的逆行标记神经元。这些研究的数据表明，分离的前和后中央传入腹侧被盖区和楔状核，分别。这些研究结果有关的皮质cunctoconut投射在猴子讨论有关（1）之间的平行猴和猫（2）可能的生理意义的解剖组织描述，和（3）在神经生理学观察中获得的矛盾的证据，由早期的研究人员，通过逆向和顺向激活这一途径。
The organization of the corticocuneate pathway was investigated in monkeys by using the anterograde and retrograde axonal transport of either horseradish peroxidase (HRP) or wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP). Injection of either tracer into the precentral cortex (centered on area 4) results in heavy anterograde labeling in the tegmental region, which lies immediately ventrolateral to the cuneate nucleus, particularly at levels caudal to the obex. On the other hand, injections of the same tracers involving areas 3b, 1, and 2 cause anterograde labeling mainly within the core (pars rotunda of Ferraro and Barrera, ''35, Arch. Neurol. Psychol. 33:262-75) of the cuneate nucleus. Anterograde labeling is also evident in the rostral parts of the cuneate nucleus, especially after injections involving areas 1 and 2. Injections restricted largely to area 3b cause anterograde labeling preferentially in the core of the cuneate nucleus. After injection of HRP or WGA-HRP into the dorsal medulla, retrogradely labeled neurons are present both in the pre- and postcentral gyrus, but their location depends upon the sites and extent of the injection site. When the tracer diffuses into the underlying tegmental area, many retrogradely labeled neurons appear in the precentral motor cortex, principally in area 4 although some of them also occur in area 6. With smaller injections, largely restricted within the cuneate nucleus, most labeled neurons are present in the postcentral gyrus, with the largest population in areas 1 and 2; a smaller number of small neurons in area 3b are best demonstrated with WGA-HRP; and area 3a contains the smallest complement of retrogradely labeled neurons. The data from these studies suggest a segregation of pre- and postcentral afferents in the ventral tegmental region and the cuneate nucleus, respectively. These findings pertaining to the corticocuneate projection in the monkey are discussed in relation to (1) the parallelism between monkeys and cats (2) possible physiological implications of the anatomical organization described, and (3) conflicting evidence in the neurophysiological observations obtained, by earlier investigators, by antidromic and orthodromic activation of this pathway.