Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U.S. adults.
Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U.S. adults.
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DOI：
10.2337/dc10-1260
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发表时间：
2011-01
期刊：
影响因子：
16.2
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Song Y;Xu Q;Park Y;Hollenbeck A;Schatzkin A;Chen H
了解复合维生素使用与糖尿病风险之间的关系非常重要，因为复合维生素补充剂在美国成年人中广泛使用。我们前瞻性地检查了1995-1996年评估的补充多种维生素和单独维生素和矿物质与2000年后诊断的232，007名参与者中自我报告的糖尿病的关系，这些参与者参加了美国国立卫生研究院-美国退休人员饮食与健康研究协会。在基线时通过食物频率问卷评估复合维生素的使用情况。通过logistic回归模型计算比值比（OR）和95% CI，并对潜在混杂因素进行调整。总共有14，130例2000年后诊断的糖尿病病例被纳入分析。在调整了潜在的混杂因素和个体补充剂的使用后，频繁使用任何多种维生素与糖尿病的风险无关。与未使用任何多种维生素的患者相比，使用者的多变量OR为1.07（95% CI 0.94-1.21）每周服用维生素少于一次，0.97（0.88-1.06）每周1 - 3次，0.92（0.84-1.00）每周4 - 6次，和1.02（0.98-1.06）每周7次或更多次（趋势P = 0.64）。糖尿病的风险显著降低与使用维生素C或钙补充剂有关。维生素C补充剂和钙补充剂每日使用者与非使用者比较的多变量OR分别为0.91（0.86-0.97）和0.85（0.80-0.90）。使用维生素E或其他维生素和矿物质补充剂与糖尿病风险无关。在这个大型的美国老年人队列中，复合维生素的使用与糖尿病风险无关。经常服用维生素C或钙补充剂的人患糖尿病的风险较低，这一发现值得进一步评估。
Understanding the relationship between multivitamin use and diabetes risk is important given the wide use of multivitamin supplements among U.S. adults. We prospectively examined supplemental use of multivitamins and individual vitamins and minerals assessed in 1995–1996 in relation to self-reported diabetes diagnosed after 2000 among 232,007 participants in the National Institutes of Health–American Association of Retired Persons Diet and Health Study. Multivitamin use was assessed by a food-frequency questionnaire at baseline. Odds ratios (ORs) and 95% CIs were calculated by logistic regression models, adjusted for potential confounders. In total, 14,130 cases of diabetes diagnosed after 2000 were included in the analysis. Frequent use of any multivitamins was not associated with risk of diabetes after adjustment for potential confounders and uses of individual supplements. Compared with nonusers of any multivitamins, the multivariate ORs among users were 1.07 (95% CI 0.94–1.21) for taking vitamins less than once per week, 0.97 (0.88–1.06) for one to three times per week, 0.92 (0.84–1.00) for four to six times per week, and 1.02 (0.98–1.06) for seven or more times per week (P for trend = 0.64). Significantly lower risk of diabetes was associated with the use of vitamin C or calcium supplements. The multivariate ORs comparing daily users with nonusers were 0.91 (0.86–0.97) for vitamin C supplements and 0.85 (0.80–0.90) for calcium supplements. Use of vitamin E or other individual vitamin and mineral supplements were not associated with diabetes risk. In this large cohort of U.S. older adults, multivitamin use was not associated with diabetes risk. The findings of lower diabetes risk among frequent users of vitamin C or calcium supplements warrant further evaluations.