Effects of age and level of physical activity on plasma norepinephrine kinetics.
Effects of age and level of physical activity on plasma norepinephrine kinetics.
复制标题
年龄和体力活动水平对血浆去甲肾上腺素动力学的影响。
DOI：
10.1152/ajpendo.1990.258.2.e256
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
DanforthJr,E
中科院分区：
文献类型：
--
作者：
Poehlman,ET;McAuliffe,T;DanforthJr,E
我们研究了年龄和体力活动对活跃和不活跃的老年人和年轻人血浆去甲肾上腺素（NE）动力学的影响。通过计算氚化去甲肾上腺素[（3 H）-NE]输注期间NE出现和清除率来估计NE动力学。相对于年轻男性和不活跃的老年男性，活跃的老年男性具有最高水平的血浆NE（pg/ml）和NE外观（微克.min-1.FFW-1，其中FFW是去脂体重）。NE清除率（1.min-1.FFW-1）不受年龄或体力活动的影响。体脂百分比、仰卧位血压与NE静息水平、NE出现和NE清除率之间无显著相关性。我们的结论是：1）老年男性长期参与体力活动，而不是年轻男性，与较高的静息血浆NE水平和NE外观相关; 2）肥胖程度不影响健康的年轻和老年男性的血浆NE动力学。体力活动水平是影响健康老年男性血浆去甲肾上腺素和去甲肾上腺素进入循环的因素。
We examined the effects of age and physical activity on plasma norepinephrine (NE) kinetics in active and inactive older and younger men. NE kinetics were estimated by calculation of the rates of NE appearance and clearance during infusion of tritiated norepinephrine [( 3H]-NE). Older active men had the highest level of plasma NE (pg/ml) and NE appearance (microgram.min-1.FFW-1, where FFW is fat-free weight) relative to younger men and inactive older men. NE clearance (l.min-1.FFW-1) was not influenced by age or physical activity. No significant associations were noted between percent body fat, supine blood pressure with resting levels of NE, NE appearance, and NE clearance. We concluded that 1) chronic participation in physical activity by older men, but not younger men, is associated with higher resting levels of plasma NE and NE appearance and 2) the degree of adiposity does not influence plasma NE kinetics in healthy younger and older men. The level of physical activity is an influencing factor on plasma NE and NE appearance into circulation in healthy older men.