Cerebral tissue oxygenation measured by two different probes: challenges and interpretation
Cerebral tissue oxygenation measured by two different probes: challenges and interpretation
复制标题
通过两种不同探头测量的脑组织氧合：挑战和解释
作者：
J. Dengler;Christine Frenzel;P. Vajkoczy;S. Wolf;P. Horn
脑组织氧合（PbO 2）最常使用Licox CC1.SB系统（LX，Integra Neuroscience，France）进行监测，但最近不同的制造商（Raumedic，德国）推出了一种新的探头-Neurovent-PTO（NV）。没有关于这些探头在临床常规中如何比较的前瞻性数据。因此，我们比较了这两种探头在昏迷患者患有创伤性脑损伤（TBI）或蛛网膜下腔出血（SAH）的动态变化的吸入氧分数（FiO 2）和平均动脉压（MAP）。方法连续记录11例患者的PbO 2的LX和NV探头并排放置在同一脑血管区域。达到稳定基线值后，FiO 2增加20%，持续10分钟。一旦重新建立基线值，MAP增加20 mmHg，持续10分钟。采用4参数Logistic函数和Bland-Altman分析进行评价。LX探针对FiO 2和MAP变化的反应明显更快。一致性的限值范围为-32.1 ~20.0 mmHg。平均LX值为6.1毫米汞柱低于NV value.ConclusionsSince检查的患者队列是相当小的，这项研究的结果是初步的。然而，他们认为LX和NV探头在常规监测以及FiO 2和MAP动态变化阶段测量不同的PbrO 2值。因此，这些数据不支持两种探头可以互换使用的观点。
PurposeCerebral tissue oxygenation (PbrO2) is most frequently monitored using a Licox CC1.SB system (LX, Integra Neuroscience, France) but recently a new probe—the Neurovent-PTO (NV)—was introduced by a different manufacturer (Raumedic, Germany). There are no prospective data on how these probes compare in clinical routine. We therefore compared both probes in comatose patients suffering from traumatic brain injury (TBI) or subarachnoid haemorrhage (SAH) during dynamic changes of inspirational oxygen fraction (FiO2) and mean arterial pressure (MAP).MethodsPbrO2 in 11 patients was recorded continuously using an LX and NV probe placed side by side into the same cerebrovascular region. Once a steady baseline value was reached FiO2 was increased by 20% for 10 min. Once the baseline values were re-established MAP was increased by 20 mmHg for 10 min. Evaluation was performed using a four-parameter logistic function and Bland–Altman analyses.ResultsPbrO2 values of both probes differed significantly at all times. The LX probe reacted significantly faster to changes in FiO2 and MAP. Limits of agreement ranged between −32.1 and 20.0 mmHg. Mean LX values were 6.1 mmHg lower than NV values.ConclusionsSince the examined patient cohort was rather small, this study’s results are preliminary. However, they suggest that LX and NV probes measure different PbrO2 values in routine monitoring as well as during phases of dynamic changes in FiO2 and MAP. These data therefore do not support the view that both probes can be used interchangeably.
影响因子：
8.8
作者：
Valadka, AB;Gopinath, SP;Robertson, CS
通讯作者：
Robertson, CS