Silver-Laden Black Phosphorus Nanosheets for an Efficient In Vivo Antimicrobial Application
Silver-Laden Black Phosphorus Nanosheets for an Efficient In Vivo Antimicrobial Application
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载银黑磷纳米片可实现高效的体内抗菌应用
DOI：
10.1002/smll.201905938
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发表时间：
2020-03-01
期刊：
影响因子：
13.3
通讯作者：
Wang, Fuan
中科院分区：
文献类型：
--
作者：
Liang, Meijuan;Zhang, Minyi;Wang, Fuan
纳米杀菌剂代表了消除细菌感染的最有效和最有前途的策略之一，考虑到传统抗生素的耐药性威胁日益增加。黑磷（BP）是最令人兴奋的后石墨烯层状2D纳米材料，具有令人信服的理化性质，但基于BP的抗生素的研究仍处于起步阶段。在这里，一个紧凑的银纳米粒子（AgNP）掺杂的黑磷纳米片（BPN）的构建，协同提高太阳能消毒通过促进活性氧（ROS）的光生，这是由于改善的电子-空穴分离和重组的BPN从系统的实验研究揭示。一个深入的密度泛函理论（DFT）计算证实，集成的AgNP提供了一个优选的网站，促进吸附和激活的O-2，从而促进更有效和强大的活性氧生成的BPN-AgNP纳米杂化物。除了增强的光诱导活性氧，锚定的银纳米粒子同时导致对细菌的亲和力显着增加，这有利于协同病原体灭活。值得注意的是，令人信服的抗微生物BPN-AgNP有助于显著的伤口愈合和体内抗微生物能力，同时使生物负荷最小化。这种新型2D纳米杂化物的复杂设计为进一步开发基于BP的纳米杂化物在便携式绷带和广谱消毒应用中开辟了新的途径。
Nanobactericides represent one of the most efficient and promising strategies for eliminating bacterial infection considering the increasing resistance threats of conventional antibiotics. Black phosphorus (BP) is the most exciting postgraphene layered 2D nanomaterial with convincing physiochemical properties, yet the study of BP-based antibiotics is still in its infancy. Here, a compact silver nanoparticle (AgNP)-doped black phosphorus nanosheet (BPN) is constructed to synergistically enhance solar disinfection through the promoted reactive oxygen species (ROS) photogeneration, which is attributed to the improved electron-hole separation and recombination of BPNs as revealed from the systematic experimental studies. An in-depth density functional theory (DFT) calculation confirms that the integrated AgNPs provide a preferred site for facilitating the adsorption and activation of O-2, thus promoting the more efficient and robust ROS generation on BPN-AgNP nanohybrids. Besides the enhanced photoinduced ROS, the anchored AgNPs simultaneously lead to a dramatically increased affinity toward bacteria, which facilitates a synergetic pathogen inactivation. Significantly, the convincing antimicrobial BPN-AgNP contributes to the prominent wound healing and antimicrobial ability in vivo with minimized biological burden. This sophisticated design of new 2D nanohybrids opens a new avenue for further exploiting BP-based nanohybrids in portable bandage and broad-spectrum disinfection applications.