Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma
Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma
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DOI：
10.4049/jimmunol.171.2.1016
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发表时间：
2003-07-15
影响因子：
4.4
通讯作者：
Pauwels, R
中科院分区：
文献类型：
--
作者：
Vermaelen, KY;Cataldo, D;Pauwels, R
树突状细胞（DC）似乎在战略上与包括哮喘在内的过敏性疾病有关。基质金属蛋白酶（MMP）-9介导地下膜炎症白细胞的移民。这项研究调查了MMP-9在过敏原引起的气道炎症过程中的气道直流运输中的作用。 MMP-9基因缺失以特定的方式影响了肺DC的运输：只有DC的炎症迁移到气道管腔中的炎症迁移受到损害，而DC介导的气道AG向胸腔淋巴结的运输仍未受到影响。同时，局部产生Th2吸引趋化因子CC趋化因子配体17/Thymus和激活调节的趋化因子高度浓缩在纯化的肺DC中，在过敏原暴露的MMP-9（----）的气道中均短缺。老鼠。这伴随着明显降低的环节嗜酸性浸润，并损害了过敏原特异性IgE的产生。我们得出的结论是，MMP-9活性的具体缺失通过损害DC募集到气道中并局部生产DC衍生的促促促促趋前的趋化因子来抑制过敏性气道炎症的发展。
Dendritic cells (DCs) appear to be strategically implicated in allergic diseases, including asthma. Matrix metalloproteinase (MMP)-9 mediates transmigration of inflammatory leukocytes across basement membranes. This study investigated the role of MMP-9 in airway DC trafficking during allergen-induced airway inflammation. MMP-9 gene deletion affected the trafficking of pulmonary DCs in a specific way: only the inflammatory transmigration of DCs into the airway lumen was impaired, whereas DC-mediated transport of airway Ag to the thoracic lymph nodes remained unaffected. In parallel, the local production of the Th2-attracting chemokine CC chemokine ligand 17/thymus and activation-regulated chemokine, which was highly concentrated in purified lung DCs, fell short in the airways of allergen-exposed MMP-9(-/-) mice. This was accompanied by markedly reduced peribronchial eosinophilic infiltrates and impaired allergen-specific IgE production. We conclude that the specific absence of MMP-9 activity inhibits the development of allergic airway inflammation by impairing the recruitment of DCs into the airways and the local production of DC-derived proallergic chemokines.