Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors.
Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors.
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DOI：
10.1021/nn5029955
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发表时间：
2014-08-26
期刊：
影响因子：
17.1
通讯作者：
Zhao, Yiping
中科院分区：
文献类型：
--
作者：
Cheng, Rui;Huang, Weijie;Huang, Lijie;Yang, Bo;Mao, Leidong;Jin, Kunlin;ZhuGe, Qichuan;Zhao, Yiping
组织型纤溶酶原激活剂（t-PA）溶栓治疗的剂量控制和疗效提高对减轻脑卒中治疗中出血等严重副作用至关重要。为了增加有效性并降低中风治疗的风险，我们使用旋转磁性纳米马达来增强t-PA分子在血凝块界面处的质量运输，用于局部缺血性中风治疗。体外实验表明，当与磁激活纳米马达组合时，低浓度t-PA（50 μg mL-1）的溶栓速度可提高高达2倍，达到高浓度t-PA时的最大溶解速度。基于对流增强传输理论，由于旋转的磁性纳米电机，提出了一个理论模型，并预测实验结果合理。这种增强治疗的有效性和效率已在大鼠栓塞模型中得到证实。
Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 μg mL–1) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.
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影响因子：
3.4
作者：
DIAMOND, SL;ANAND, S
通讯作者：
ANAND, S
影响因子：
13.3
作者：
He, Yuping;Fu, Junxue;Cai, Janwang
通讯作者：
Cai, Janwang
DOI：
10.1016/0735-1097(92)90459-z
发表时间：
1992-12-01
影响因子：
24
作者：
PREWITT, RM;GU, SA;DUCAS, J
通讯作者：
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影响因子：
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作者：
Del Zoppo GJ;Saver JL;Jauch EC;Adams HP Jr;American Heart Association Stroke Council
通讯作者：
American Heart Association Stroke Council
影响因子：
5.5
作者：
Marsh, J. N.;Senpan, A.;Lanza, G. M.
通讯作者：
Lanza, G. M.