Anogenital distance is associated with serum reproductive hormones, but not with semen quality in young men
Anogenital distance is associated with serum reproductive hormones, but not with semen quality in young men
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肛门生殖器距离与血清生殖激素有关，但与年轻男性的精液质量无关。
DOI：
10.1093/humrep/dew052
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发表时间：
2016-05-01
影响因子：
6.1
通讯作者：
Cao, Jia
中科院分区：
文献类型：
--
作者：
Zhou, Niya;Sun, Lei;Cao, Jia
研究问题：男性肛门生殖器距离与精液参数和血清生殖激素水平相关吗？总结回答：肛门生殖器距离与血清生殖激素有关，但与精液质量无关。已知：流行病学研究表明，肛门生殖器距离（AGD）可能与成年男性睾丸功能障碍有关。研究设计、规模、持续时间：我们于2014年6月在重庆大学生男性生殖健康（MARHCSs）队列研究中检测了656名年轻大学生的AGD与精液参数和生殖激素水平之间的关系。参与者/材料、地点、方法：本研究对656名大学生进行了AGD（AP）和AGD（AS）的测量。检测血清睾酮（T）、雌二醇（E2）、孕酮（P）、催乳素（PRL）、促黄体生成素（LH）、促卵泡激素（FSH）、性激素结合球蛋白（SHBG）和卵泡刺激素-B水平;以及精液质量结局，包括精液量、精子浓度、精子总数、精子前向运动力、总运动力和形态。AGD与精液参数/生殖激素水平之间的关系采用多元回归分析。主要结果和机会的作用：AGD（AS）和AGD（AP）与任何精液参数均不相关。在非参数相关分析中，AGD（AP）与精子前向运动力、生殖激素E2、睾酮、SHBG及睾酮/LH比值相关。体重指数（BMI）与血清睾酮水平呈显著正相关（r =-0.216，P = 0.001）。
STUDY QUESTION: Is anogenital distance associated with semen parameters and serum reproductive hormone levels in males?SUMMARY ANSWER: Anogenital distance is associated with serum reproductive hormones, but not with semen quality.WHAT IS KNOWN ALREADY: Epidemiological studies have suggested that anogenital distance (AGD) may be associated with testicular dysfunction in adult men. However, the role of AGD in estimating male reproductive function remains unclear.STUDY DESIGN, SIZE, DURATION: We examined the associations between AGD and semen parameters and reproductive hormones levels in 656 young college students in a Male Reproductive Health in Chongqing College Students (MARHCSs) cohort study in June of 2014.PARTICIPANTS/MATERIALS, SETTING, METHODS: In this study, two variants of AGD(AGD(AP) and AGD(AS)) were measured in 656 university students. Serum levels of testosterone (T), estradiol (E2), progesterone (P), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG) and inhibin-B; and semen quality outcomes, including semen volume, sperm concentration, total sperm number, sperm progressive motility, total motility and morphology, were assessed. The associations between AGD and semen parameters/reproductive hormones levels were analyzed using multiple regression analysis.MAIN RESULTS AND THE ROLE OF CHANCE: Both AGD(AS) and AGD(AP) were not associated with any semen parameters. In the nonparametric correlation analysis, AGD(AP) were correlated with sperm progressive motility and reproductive hormones of E2, testosterone, SHBG and the testosterone/LH ratio. However, body mass index (BMI) also significantly correlated with serum testosterone (r = -0.216, P =