Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis.
Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis.
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DAPK1 甲基化与胃肠道癌症风险的相关性：系统评价和荟萃分析
DOI：
10.1371/journal.pone.0184959
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Shu X
中科院分区：
文献类型：
--
作者：
Yuan W;Chen J;Shu Y;Liu S;Wu L;Ji J;Liu Z;Tang Q;Zhou Z;Cheng Y;Jiang B;Shu X
目的死亡相关蛋白激酶1（DAPK 1）基因启动子区甲基化异常导致DAPK 1基因沉默是胃肠道肿瘤发生的重要机制之一。然而，DAPK 1甲基化与胃肠道癌风险之间的关系仍然存在争议。因此，我们进行了这项研究，以确定潜在的相关性。方法根据纳入标准和排除标准，检索Pubmed、Embase和科克伦图书馆截至2016年11月的符合条件的文献。采用Revman 5.3和Stata 12.0软件分析DAPK 1甲基化频率与胃肠道肿瘤相关性的相关数据。结果共纳入22篇文献，2406例患者。DAPK 1甲基化与胃肠道癌风险呈正相关（OR = 5.35，95%可信区间（CI）：2.76-10.38，P<0.00001，随机效应模型）。通过敏感性分析和亚组分析分析异质性的来源。在省略一项异质性研究后，在汇总分析中，I2降低，OR增加。此外，在样本量小于60例的研究亚组中，异质性降低最显著。分析DAPK 1甲基化与胃肠道肿瘤临床病理特征的关系。DAPK 1甲基化与淋巴结（N）分期呈正相关（阳性vs阴性，OR = 1.45，95%CI：1.01-2.06，P = 0.04，固定效应模型）和分化差（OR = 1.55，95%CI：1.02-2.35，P = 0.04，固定效应模型），亚洲患者中相关性显著。然而，在胃肠道癌病例中，DAPK 1甲基化与肿瘤（T）分期、N分期、远处转移（M）分期和癌症分化之间的关联没有统计学意义。结论DAPK 1甲基化是胃肠道肿瘤早期诊断的一个潜在生物标志物。进一步的临床病理学分析表明，DAPK 1异常甲基化与胃肠道肿瘤的发生、胃癌的转移呈正相关。
Objective One of the critical mechanisms of gastrointestinal cancer pathogenesis is the silencing of death associated protein kinase 1 (DAPK1), which could be caused by aberrant methylation of the promoter. However, the relationship between DAPK1 methylation and the risk of gastrointestinal cancer is still controversial. Hence, we conducted this study to determine the potential correlation. Methods Eligible publications were searched in the Pubmed, Embase, and Cochrane Library through November 2016 according to the inclusion criteria and exclusion criteria. Revman 5.3 and Stata 12.0 software were used to analyze the relevant data regarding the association between the frequency of DAPK1 methylation and gastrointestinal cancer. Results A total of 22 studies with 2406 patients were included in this meta analysis. Methylation of DAPK1 was positively related with the risk of gastrointestinal cancer (odds ratio [OR] = 5.35, 95% confidence interval [CI]: 2.76–10.38, P<0.00001, random effects model). The source of heterogeneity was analyzed by sensitivity analysis and subgroup analysis. After omitting one heterogeneous study, the I2 decreased and the OR increased in pooled analysis. Also, the heterogeneity decreased most significantly in the subgroup of studies that had a sample size of less than 60 cases. Then, the correlations between DAPK1 methylation and clinicopathological features of gastrointestinal cancer were assessed. DAPK1 methylation was positively correlated with the lymph node (N) stage (positive vs. negative, OR = 1.45, 95%CI: 1.01–2.06, P = 0.04, fixed effects model) and poor differentiation (OR = 1.55, 95%CI: 1.02–2.35, P = 0.04, fixed effects model) in gastric cancer, and the association was significant among Asian patients. However, among cases of gastrointestinal cancer, the association between DAPK1 methylation and tumor (T) stage, N stage, distant metastasis (M) stage, and cancer differentiation were not statistically significant. Conclusions DAPK1 methylation is a potential biomarker for the early diagnosis of gastrointestinal cancer. Further analysis of the clinicopathological features indicated that aberrant methylation of DAPK1 is positively associated with the tumorigenesis of gastrointestinal cancer, and metastasis of gastric cancer.
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影响因子：
4.8
作者：
Kuester, Doerthe;Dar, Altaf A.;Schneider-Stock, Regine
通讯作者：
Schneider-Stock, Regine
影响因子：
5
作者：
Lee, S;Hwang, KS;Kang, GH
通讯作者：
Kang, GH
影响因子：
11.2
作者：
Hughes, Laura A. E.;Melotte, Veerle;van Engeland, Manon
通讯作者：
van Engeland, Manon
影响因子：
4.6
作者：
Laskar, Ruhina Shirin;Ghosh, Sankar Kumar;Talukdar, Fazlur Rahman
通讯作者：
Talukdar, Fazlur Rahman
影响因子：
10.5
作者：
DEISS, LP;FEINSTEIN, E;KIMCHI, A
通讯作者：
KIMCHI, A