Discouraging soft drink consumption reduces blood glucose and cholesterol of Brazilian elementary students: Secondary analysis of a randomized controlled trial
Discouraging soft drink consumption reduces blood glucose and cholesterol of Brazilian elementary students: Secondary analysis of a randomized controlled trial
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DOI：
10.1016/j.ypmed.2017.04.035
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发表时间：
2017-07-01
影响因子：
5.1
通讯作者：
Sichieri, Rosely
中科院分区：
文献类型：
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作者：
de Moraes, Milena Miranda;Felix Mediano, Mauro Felippe;Sichieri, Rosely
本研究的目的是评估旨在阻止含糖碳酸饮料摄入的教育计划对空腹血糖和总胆固醇的影响。在里约热内卢的尼泰罗伊市，22所学校的47个四年级班级参加了一项随机对照试验，旨在阻止软饮料的摄入，以防止在一个学年中体重过度增加。在1140名随机分配的学生中，478名（干预组238名，对照组240名）年龄在912岁的学生至少有一项生化数据结果，并进行分析，以评估干预对随访结束时空腹血糖和总胆固醇变化的影响。进行意向治疗分析，考虑到聚类（类别）效应。与对照组相比，干预组学生的空腹血糖（-9.12 mg/dL vs. + 0.51 mg/dL，p < 0.001）和总胆固醇（-10.34 mg/dL vs. + 2.14 mg/dL，p < 0.001）在统计学上显著降低。此外，干预组空腹血糖受损和高胆固醇血症的患病率降低，对照组升高（分别为-2.4% vs. +8.8%，p = 0.04和-10.0% vs. +2.7%，p = 0.03）。令人沮丧的软饮料消费在儿童中导致空腹血糖和总胆固醇的降低，这表明这些饮料可能在儿童心脏代谢风险的发展中发挥作用。(C)2017爱思唯尔公司All rights reserved.
The objective of this study was to evaluate the effect of an educational program aimed at discouraging sugar-sweetened carbonated beverages intake on blood fasting glucose and total cholesterol. Forty-seven fourth grade classes in twenty-two schools have participated in a randomized controlled trial aimed at discouraging soft drink intake in order to prevent excessive weight gain during a school year, in the city of Niteroi, Rio de Janeiro. Of 1140 randomized students, 478 (238 in intervention group and 240 in control group) aged 912 years old had at least one result on biochemical data and were analyzed to evaluate the effect of the intervention on changes in fasting glucose and total cholesterol at the end of follow-up. Intention-to-treat analysis was performed taking into account the cluster (classes) effect. Statistically significant decrease in fasting glucose (-9.12 mg/dL vs. + 0.51 mg/dL, p < 0.001) and total cholesterol (-10.34 mg/dL vs. + 2.14 mg/dL, p < 0.001) were observed among students in the intervention group in comparison with controls. In addition, the prevalence of impaired fasting glucose and hypercholesterolemia decreased in interventions and increased in controls (-2.4% vs. + 8.8%, p = 0.04 and -10.0% vs. + 2.7%, p = 0.03, respectively). Discouraging soft drink consumption among children has led to a reduction in fasting glucose and total cholesterol, suggesting that these beverages may play a role in the development of cardiometabolic risk in childhood. (C) 2017 Elsevier Inc. All rights reserved.