Protective effect of bamboo shoot oil on experimental nonbacterial prostatitis in rats
Protective effect of bamboo shoot oil on experimental nonbacterial prostatitis in rats
复制标题
竹笋油对大鼠实验性非细菌性前列腺炎的保护作用
DOI：
10.1016/j.foodchem.2010.07.066
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发表时间：
2011-02-01
期刊：
影响因子：
8.8
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Lu, Baiyi;Cai, Huafang;Zhang, Ying
目的探讨竹笋油对非细菌性前列腺炎的保护作用及其机制。采用消痔灵诱导的大鼠实验性NBP模型，以前列腺重量、酸性磷酸酶、卵磷脂小体密度（DLCC）、白色细胞计数（WBC）和前列腺组织形态学指标评价BSO的抗前列腺炎作用。采用功能聚焦基因芯片和实时荧光定量PCR技术研究其抗前列腺炎作用机制。BSO可显著抑制前列腺绝对重量、前列腺指数、总酸性磷酸酶、前列腺酸性磷酸酶、WBC及30个上调基因的表达水平，而BSO可显著增加DLCC及15个下调基因的表达水平。在组织学上，BSO治疗显著抑制了NBP-induced大鼠病变的严重程度。因此，BSO可用于治疗NBP，因为它可通过影响炎性细胞因子、其受体和相关基因的表达来抑制NBP患者的前列腺炎症。(C)2010爱思唯尔有限公司版权所有。
This study aim to investigate the protective effects of bamboo shoot oil (BSO) and its mechanisms on nonbacterial prostatitis (NBP). The anti-prostatitis effect of BSO were evaluated by prostate weight, acid phosphatase, density of lecithin corpuscles (DLCC), white blood cell count (WBC), and prostatic histomorphological parameters using Xiaozhiling-induced experimental NBP model in rats. The mechanisms of anti-prostatitis effect were assessed using functionally focused cDNA microarray and real-time PCR. BSO could significantly inhibited absolute prostate weight, prostate index, total acid phosphatase, prostatic acid phosphatase, WBC and the expression levels of thirty up-regulated genes, while BSO could significantly increased DLCC and the expression levels of fifteen down-regulated genes. Histologically, BSO treatment significantly suppressed the severity of the lesion in NBP-induced rats. Thus, BSO may be useful for treatment of NBP, as it may inhibits prostate inflammation in NBP patients by affecting the expression of inflammatory cytokines, their receptors, and related genes. (C) 2010 Elsevier Ltd. All rights reserved.