Effect of seafood mediated PCB exposure on desaturase activity and PUFA profile in Faroese septuagenarians.
Effect of seafood mediated PCB exposure on desaturase activity and PUFA profile in Faroese septuagenarians.
复制标题
海鲜介导的 PCB 暴露对法罗群岛七十多岁老人去饱和酶活性和 PUFA 谱的影响。
DOI：
10.1016/j.envres.2015.06.001
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发表时间：
2015
影响因子：
8.3
通讯作者：
Grandjean,Philippe
中科院分区：
文献类型：
--
作者：
Tøttenborg,SandraSøgaard;Choi,AnnaL;Bjerve,KristianS;Weihe,Pal;Grandjean,Philippe
多氯联苯 (PCB) 暴露可能会通过抑制驱动前体脂肪酸合成的去饱和酶 Δ5 和 Δ6 来影响多不饱和脂肪酸 (PUFA) 的血清浓度。脂肪酸组成的这种变化可能会影响心血管疾病的风险，人们认为，随着多氯联苯暴露的增加，心血管疾病的风险也会增加。这项基于人群的横断面研究调查了 712 名 70-74 岁的法罗群岛男性和女性。空腹血样的血清磷脂部分用于测定PUFA谱，包括亚油酸、二高-γ-亚麻酸、花生四烯酸、二十碳三烯酸和其他相关脂肪酸。前体脂肪酸和代谢物脂肪酸之间的比率用作 Δ5 和 Δ6 去饱和酶活性的代表。血清 PCB 浓度的三分位数用于多元回归分析，以确定暴露与去饱和酶活性之间的关联。在多元回归模型中，PCB 暴露与估计的 Δ6 去饱和酶活性成反比，导致前体脂肪酸的积累和相应产物 PUFA 的减少。还发现 PCB 和 Δ5 去饱和度之间存在正相关关系。还观察到 EA 相对增加，但仅发生在 PCB 暴露的第三个三分位数中。未发现暴露与去饱和酶活性之间的非线性关系。如果饮食同时导致接触多氯联苯，那么食用鱼类和海鲜可能不会转化为有益的脂肪酸。尽管去饱和酶估计值可能受到多不饱和脂肪酸产品膳食摄入量的影响，但 PCB 暴露与 Δ6 去饱和酶活性之间的关联似乎是合理的，并且可能会影响心血管疾病风险。
Polychlorinated biphenyl (PCB) exposure may affect serum concentrations of polyunsaturated fatty acids (PUFAs) by inhibiting desaturases ∆5 and ∆6 that drive their synthesis from precursor fatty acids. Such changes in the composition of fatty acids may affect cardiovascular disease risk, which is thought to increase at elevated PCB exposures. This population-based cross-sectional study examined 712 Faroese men and women aged 70–74 years. The serum phospholipid fraction of fasting blood samples was used to determine the PUFA profile, including linoleic acid, dihomo-γ-linolenic acid, arachidonic acid, eicosatrienoic acid, and other relevant fatty acids. Ratios between precursor and metabolite fatty acids were used as proxies for ∆5 and ∆6 desaturase activity. Tertiles of serum-PCB concentrations were used in multiple regression analyses to determine the association between the exposure and desaturase activity. In multiple regression models, PCB exposure was inversely related to the estimated Δ6 desaturase activity resulting in accumulation of precursor fatty acids and decrease in the corresponding product PUFAs. A positive association between PCB and Δ5 desaturation was also found. A relative increase in EA was also observed, though only in the third tertile of PCB exposure. Non-linear relationships between the exposure and the desaturase activity were not found. Consuming fish and seafood may not be translated into beneficial fatty acid profiles if the diet simultaneously causes exposure to PCBs. Although the desaturase estimates were likely influenced by dietary intakes of product PUFAs, the association between PCB exposure and ∆6 desaturase activity is plausible and may affect cardiovascular disease risk.