Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture
Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture
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DOI：
10.1134/s0012500819110041
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发表时间：
2019-11-01
影响因子：
0.8
通讯作者：
Sevostyanov, M. A.
中科院分区：
文献类型：
--
作者：
Baikin, A. S.;Kaplan, M. A.;Sevostyanov, M. A.
开发了一种基于高分子量聚丙交酯生产生物相容性和可生物降解聚合物薄膜的工艺，该薄膜具有医疗和农业应用所需的特性。设计了一种将活性物质（硫酸庆大霉素、盐酸林可霉素或头孢噻肟）包含到高分子量聚丙交酯薄膜中的方法。活性物质从聚丙交酯中的释放速率可以根据衰减指数规律或几乎线性地随时间变化。活性物质的释放受到薄膜周围溶液pH值的显着影响。研究发现，基于高分子量聚丙交酯的生物相容性可生物降解聚合物薄膜释放活性物质的动力学取决于固定物质的性质、薄膜制备方法和提取条件。基于高分子量聚丙交酯的生物相容性可生物降解聚合物薄膜非常适合制造支架和假体的涂层，使药物能够长期且受控地释放到周围组织中，并适用于农业应用以改善作物保存。
A process was developed for producing biocompatible and biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A method was devised for the inclusion of active substances (gentamicin sulfate, lincomycin hydrochloride, or cefotaxime) into high-molecular-weight polylactide films. The rate of release of active substances from polylactide can vary with time according to a decaying exponential law or nearly linearly. The release of active substances is significantly affected by pH of the solution surrounding the film. It was found that the dynamics of release of active substances from biocompatible biodegradable polymer films based on high-molecular-weight polylactide depends on the properties of the immobilized substance, the film preparation method, and the conditions of extraction. The biocompatible biodegradable polymer films based on high-molecularweight polylactide are quite suitable for the manufacture of coatings for stents and prostheses with prolonged and controlled drug release into the surrounding tissues and for agricultural applications to improve crop preservation.