[Chronic neutrophilic leukemia: apropos of 2 cases and review of the literature].
[Chronic neutrophilic leukemia: apropos of 2 cases and review of the literature].
复制标题
慢性中性粒细胞白血病2例并文献复习[J].
作者：
C. Hidalgo;J. Camacho;J. Fernández;À. Hernández;F. Poveda;J. Peña
报告两例慢性中性粒细胞白血病，一种罕见的骨髓增殖性综合征，并复习文献。收集的34例病例(包括本文报告的两例)的主要特征是持续的类白血病反应的白细胞增多，肝脾肿大，高尿酸血症，维生素B12血液水平升高，白细胞碱性磷酸酶升高和费城染色体缺失。感染是导致死亡的主要原因。伴发多发性骨髓瘤8例。
Two patients with chronic neutrophilic leukemia, a rare myeloproliferative syndrome, are reported with a review of the literature. The major features of the 34 collected cases (including the two patients reported here) were persistent leukocytosis simulating a leukemoid reaction, hepatosplenomegaly, hyperuricemia, increased vitamin B12 blood level, increased leukocyte alkaline phosphatase and absence of the Philadelphia chromosome. Infection was the leading cause of death. Concomitant multiple myeloma was found in eight patients.