ALTERATIONS OF RESTING-STATE REGIONAL AND NETWORK-LEVEL NEURAL FUNCTION AFTER ACUTE SPINAL CORD INJURY
ALTERATIONS OF RESTING-STATE REGIONAL AND NETWORK-LEVEL NEURAL FUNCTION AFTER ACUTE SPINAL CORD INJURY
复制标题
DOI：
10.1016/j.neuroscience.2014.07.045
复制
发表时间：
2014-09-26
期刊：
影响因子：
3.3
通讯作者：
Li, H-T.
中科院分区：
文献类型：
--
作者：
Hou, J-M.;Sun, T. -S.;Li, H-T.
目的：研究脊髓损伤（SCI）早期脑功能改变，并进一步探讨这些功能改变与SCI患者感觉运动功能的关系。方法：采用静息状态功能磁共振成像（fMRI）对25例脊髓损伤患者和25例健康对照者进行成像。采用低频波动幅度（ALFF）表征区域神经功能，采用基于种子的功能连通性（FC）评价脑网络的功能整合。结果：与健康对照组相比，脊髓损伤患者双侧初级感觉运动皮层ALFF水平降低，双侧小脑和右侧眶额皮质ALFF水平升高。脊髓损伤患者左小脑ALFF值与临床总运动评分呈负相关。此外，SCI患者主要表现为双侧初级感觉运动皮层之间的半球间FC减少，以及运动网络（包括初级感觉运动皮层、运动前皮层、辅助运动区（SMA）、丘脑和小脑）内半球内FC增加。随后的相关分析显示，初级感觉运动皮层、SMA和小脑内FC的增加与美国脊髓损伤协会（ASIA）的总运动评分呈负相关。结论：我们的研究结果提供了证据，证明脊髓损伤可以在疾病早期诱导显著的区域和网络水平的功能改变。我们假设这些变化可能是脊髓损伤后的适应性现象，反映了脊髓损伤早期的代偿机制。(c) 2014 ibro。Elsevier Ltd.出版。版权所有。
Object: The purpose of this study was to investigate functional alterations of the brain in the early stage of spinal cord injury (SCI) and further investigate how these functional alterations relate to SCI patients' sensorimotor functions.Methods: Twenty-five patients with SCI and 25 matched healthy controls underwent imaging by using resting-state functional magnetic resonance imaging (fMRI). The amplitude of low-frequency fluctuations (ALFF) were used to characterize regional neural function, and the seed-based functional connectivity (FC) was used to evaluate the functional integration of the brain network.Results: Compared to healthy controls, patients with SCI showed decreased ALFF in the bilateral primary sensorimotor cortex, and increased ALFF in the bilateral cerebellum and right orbitofrontal cortex (OFC). The ALFF value in the left cerebellum was negatively correlated with the clinical total motor score in patients with SCI. Furthermore, SCI patients mainly showed decreased inter-hemispheric FC between the bilateral primary sensorimotor cortex, as well as increased intra-hemispheric FC within the motor network, including the primary sensorimotor cortex, premotor cortex, supplementary motor area (SMA), thalamus and cerebellum. Subsequent correlation analyses revealed that increased FC within the primary sensorimotor cortex, SMA, and cerebellum negatively correlated with the total American Spinal Cord Injury Association (ASIA) motor score.Conclusions: Our findings provide evidence that SCI can induce significant regional and network-level functional alterations in the early stage of the disease. We hypothesized these alterations may be an adaptive phenomenon following SCI, reflecting a compensatory mechanism during the early stage of SCI. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.