THE TEMPORAL DYNAMICS OF ENHANCING A HUMAN DECLARATIVE MEMORY DURING RECONSOLIDATION
THE TEMPORAL DYNAMICS OF ENHANCING A HUMAN DECLARATIVE MEMORY DURING RECONSOLIDATION
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DOI：
10.1016/j.neuroscience.2013.04.033
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发表时间：
2013-08-29
期刊：
影响因子：
3.3
通讯作者：
Delorenzi, A.
中科院分区：
文献类型：
--
作者：
Coccoz, V.;Sandoval, A. V.;Delorenzi, A.
当一个巩固的记忆被重新激活时，它会变得不稳定，容易增强或破坏，这个过程被称为重新巩固。重新巩固假说挑战了传统观点，即巩固后的记忆是固定且不可改变的。最近的研究表明，介导记忆提取的机制和记忆的行为表达的基础机制可以分离，为人类记忆持久性的理解提供了新的希望。虽然再巩固研究通常使用遗忘剂，但也有研究表明，在再巩固过程中，药物和现实生活中的事件可以增强记忆。最近，我们证明了一个温和的应激，冷加压应激（CPS），可以提高人类陈述性记忆过程中的线索回忆测试的再巩固。在这里，我们评估是否可以通过暴露于两种不同的神经调节剂来改善7天或20天的长期记忆的回忆：在再巩固过程中的轻度应激和葡萄糖。正如预期的那样，在记忆重新激活时（训练后第6天和第20天）发现记忆表现较差和非常差。在再巩固过程中，CPS改善了训练后6天而不是20天的陈述性记忆的长期表达。然而，口服葡萄糖（果汁），而不是饮食果汁，可以在训练后20天的再巩固过程中增强记忆。有趣的是，当应用识别测试而不是线索回忆测试时，记忆表现在训练后1周和3周仍然很稳健。在这里，我们表明，这段记忆可以被重新激活并变得不稳定的时间大大超过了回忆的时间，证明了有意识的访问不需要重新巩固的证据。目前的研究结果是一致的解离之间的机制介导的记忆不稳定性和记忆的行为表达的基础机制。(C)2013年IBRO。由爱思唯尔有限公司出版。保留所有权利。
When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20-day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20-days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20 days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3 weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.