Pregnancy rates for single embryo transfer (SET) of day 5 and day 6 blastocysts after cryopreservation by vitrification and slow freeze
Pregnancy rates for single embryo transfer (SET) of day 5 and day 6 blastocysts after cryopreservation by vitrification and slow freeze
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DOI：
10.1007/s10815-017-0940-4
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发表时间：
2017-07-01
影响因子：
3.1
通讯作者：
Engmann, Lawrence
中科院分区：
文献类型：
--
作者：
Kaye, Leah;Will, Erica Anspach;Engmann, Lawrence
本研究的目的是比较在第5天或第6天冷冻保存的囊胚的单胚胎移植（SET）周期中的临床和持续妊娠率。我们的目的是确定第6天的囊胚是否足以推荐SET.Retrospective队列研究，包括392名年龄小于38岁的女性在美国大学附属IVF诊所接受SET的468个移植周期。分析了2010年至2016年期间冻融SET的共261个第5天囊胚和207个第6天囊胚。数据包括通过缓慢冷冻法和玻璃化法进行的冷冻保存。总的来说，59.0%的第5天SET周期导致临床妊娠，而第6天囊胚的临床妊娠率为54.1%（p = 0.54）。第5天冻融囊胚的持续妊娠率（51.7%）与第6天相当（44.9%，p = 0.14）。当仅观察玻璃化冷冻的囊胚时，第5天和第6天的囊胚之间没有显著差异，第5天的临床妊娠率为69.2%，第6天的临床妊娠率为72.5%（p = 0.68）。第6天冷冻保存的囊胚的SET导致与第5天相比相似的临床妊娠率和持续妊娠率，特别是在玻璃化冷冻后。
The purpose of this study was to compare clinical and ongoing pregnancy rates in cycles with single embryo transfer (SET) of blastocysts cryopreserved on day 5 or day 6. Our aim was to determine whether day 6 blastocysts perform adequately to recommend SET.Retrospective cohort study including 468 transfer cycles for 392 women younger than age 38 undergoing SET at a university-affiliated IVF clinic in the USA. A total of 261 day 5 blastocysts and 207 day 6 blastocysts for frozen-thawed SET between 2010 and 2016 were analyzed. Data included cryopreservation by both a slow freeze method and vitrification.In total, 59.0% of day 5 SET cycles resulted in a clinical pregnancy compared to 54.1% of day 6 blastocysts (p = 0.54). Ongoing pregnancy rates from day 5 frozen-thawed blastocysts (51.7%) were comparable to day 6 (44.9%, p = 0.14). When looking at vitrified blastocysts only, there were no significant differences between day 5 and day 6 blastocysts, with a clinical pregnancy rate of 69.2% for day 5 and 72.5% for day 6 (p = 0.68).SETs of day 6 cryopreserved blastocysts resulted in similar clinical and ongoing pregnancy rates compared to day 5, particularly after vitrification.