Experimental and Model Study on Enantioselective Extraction of Phenylglycine Enantiomers with BINAP–Metal Complexes
Experimental and Model Study on Enantioselective Extraction of Phenylglycine Enantiomers with BINAP–Metal Complexes
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DOI：
10.1021/ie301976h
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发表时间：
2012-11
影响因子：
4.2
通讯作者：
K. Tang;Guohui Wu;Panliang Zhang;Congshan Zhou;Jiajia Liu
中科院分区：
文献类型：
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作者：
K. Tang;Guohui Wu;Panliang Zhang;Congshan Zhou;Jiajia Liu
研究了（S）-BINAP-金属配合物对苯甘氨酸（PHG）对映体的手性选择性萃取。建立了反应萃取模型来解释实验数据。通过实验确定了该模型所需的络合平衡常数等重要参数。该萃取体系对PHG对映体具有良好的选择性。[（S）-BINAP（CH_3CN）Cu][PF_6]（BINAP-Cu）在所研究的选择剂中表现出最高的选择性，它溶解在有机相中并优先从水相中萃取l-PHG。萃取效率通常强烈地取决于许多工艺变量，包括有机溶剂和金属前体的类型、选择剂的浓度、pH和温度。该模型定量预测提取性能的关键操作参数的函数，提供了一个简单的计算方法，过程优化。该模型得到了实验验证，具有良好的鲁棒性。
Enantioselective extraction of phenylglycine (PHG) enantiomers with (S)-BINAP–metal complexes as chiral selector was investigated. A reactive extraction model was established to interpret the experimental data. The complexation equilibrium constants and other important parameters required by the model were determined experimentally. The extraction system shows good selectivity toward PHG enantiomers. The complex [(S)-BINAP(CH3CN)Cu][PF6] (BINAP–Cu) exhibits the highest selectivity among the selectors studied, which is dissolved in the organic phase and preferentially extracts l-PHG from aqueous phase. Efficiency of extraction depends, often strongly, on a number of process variables, including types of organic solvents and metal precursors, concentration of selector, pH, and temperature. The model quantitatively predicts extraction performance as a function of key operating parameters, providing a simple computational approach to process optimization. The model was verified experimentally with excellent r...