The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity.
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity.
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DOI：
10.1016/j.biopsych.2013.12.015
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发表时间：
2015-10-15
影响因子：
10.6
通讯作者：
Nutt DJ
中科院分区：
文献类型：
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作者：
Carhart-Harris RL;Murphy K;Leech R;Erritzoe D;Wall MB;Ferguson B;Williams LT;Roseman L;Brugger S;De Meer I;Tanner M;Tyacke R;Wolff K;Sethi A;Bloomfield MA;Williams TM;Bolstridge M;Stewart L;Morgan C;Newbould RD;Feilding A;Curran HV;Nutt DJ
化合物3，4-亚甲二氧基甲基苯丙胺（MDMA）是一种有效的单胺麻醉剂，在大多数人中产生急性欣快感。在一项双盲、安慰剂对照、平衡顺序研究中，25名身心健康的个体口服MDMA。使用动脉自旋标记和基于种子的静息状态功能连接（RSFC）来产生空间图，显示MDMA给药后脑血流量（CBF）和RSFC的变化。参与者在90分钟的扫描时间内接受了两次动脉自旋标记和两次血氧水平依赖性扫描; MDMA和安慰剂研究日间隔1周。积极情绪的显著增加是由MDMA产生的。仅在MDMA后观察到CBF降低，并且这局限于右内侧颞叶（MTL）、丘脑、下视觉皮层和躯体感觉皮层。右侧杏仁核和海马的CBF降低与MDMA的总体主观效应强度评级相关。RSFC结果补充了CBF结果，中线皮质区域、内侧前额叶皮质和MTL区域之间的RSFC减少，杏仁核和海马之间的RSFC增加。这些影响与强烈和积极的主观影响评级之间存在趋势水平相关性。MTLs似乎特别涉及MDMA的作用机制，但需要进一步的工作来阐明该药物的特征性主观效应是如何从其对自发脑活动的调节中产生的。
The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. In a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling and seed-based resting state functional connectivity (RSFC) were used to produce spatial maps displaying changes in cerebral blood flow (CBF) and RSFC after MDMA administration. Participants underwent two arterial spin labeling and two blood oxygen level–dependent scans in a 90-minute scan session; MDMA and placebo study days were separated by 1 week. Marked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and hippocampus correlated with ratings of the intensity of global subjective effects of MDMA. The RSFC results complemented the CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex, and MTL regions, and increases between the amygdala and hippocampus. There were trend-level correlations between these effects and ratings of intense and positive subjective effects. The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug’s characteristic subjective effects arise from its modulation of spontaneous brain activity.