Reparation of the fetal eye following radiation insult.
Reparation of the fetal eye following radiation insult.
复制标题
辐射损伤后胎儿眼睛的修复。
DOI：
10.1001/archopht.1955.00930020357004
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发表时间：
1955
期刊：
影响因子：
--
通讯作者：
J. Wolff
中科院分区：
文献类型：
--
作者：
R. Rugh;J. Wolff
辐射损伤是即时的，但这种损伤的细胞学证据可能不会持续数小时或数天，这至少部分取决于所研究的特定组织的活性。暴露后几天暴露组织的组织学和细胞学分析没有显示发生的立即破坏和随后的修复过程。这项对非常早期的、因而对辐射敏感的胚胎眼睛的研究，是为了揭示对x射线的分级照射的反应顺序。它揭示了胚胎中存在的非凡的修复能力。材料和方法将CF 1雌性小鼠与相同品系的雄性小鼠定时交配，12.5天后暴露于全身X射线辐射。通过在210 kvp和15 ma下运行的Quandrocondex恒电位治疗机实现照射，用0.28 mm Cu和0.50 mm Al过滤，使射线选择性硬化。
Radiation insult is immediate, but the cytological evidence for this insult may not follow for hours or days, depending, in part at least, upon the activity of the particular tissue under study. Histological and cytological analyses of exposed tissues days after exposure have not revealed the immediate disruptive and the subsequent reparative processes that occur. This study of the very early, and consequently radiosensitive, embryonic eye is made to bring out the sequence of responses to graded exposures of x-radiation. It reveals the remarkable powers of repair present in the embryo. MATERIALS AND METHOD CF1 female mice were time-mated with males of the same strain and 12.5 days later were exposed to whole-body x-radiations. Irradiation was achieved by a Quandrocondex constant-potential therapy machine run at 210 kvp and 15 ma., and the rays were selectively hardened by filtration with 0.28 mm. Cu and 0.50 mm. Al. The distance to the