Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place.
Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place.
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DOI：
10.1073/pnas.0409726102
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发表时间：
2005-02
影响因子：
11.1
通讯作者：
A. Tran;R. Tamura;T. Uwano;Tsuneyuki Kobayashi;M. Katsuki;T. Ono
中科院分区：
文献类型：
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作者：
A. Tran;R. Tamura;T. Uwano;Tsuneyuki Kobayashi;M. Katsuki;T. Ono
预测奖励在学习接近行为中是必不可少的。多巴胺能活动与奖赏、运动和认知过程有关，这些都是学习的基本要素。丘脑核（NAc）接受来自皮质边缘信息处理区和起源于腹侧被盖区的中脑边缘多巴胺神经元的会聚输入。以前，我们报道，在小鼠中，多巴胺D2受体敲除（D2 R-KO）消除了奖励前抑制反应，增加了NAc神经元的位置场大小，并减少了运动活动，而颅内自我刺激（ICSS）行为没有显着变化。本研究探讨了多巴胺D1受体（D1 R）在介导奖赏、自发活动、空间联想过程和调节NAc神经反应中的具体作用。与D2 R-KO动物相比，我们发现D1 R-KO小鼠选择性地消除了前奖赏兴奋反应，并减少了NAc神经元的位置场大小。此外，D1 R-KO损害ICSS行为，严重减少自发活动，并延迟位置学习任务的获得。因此，本研究结果表明，D1 R可能是一个重要的决定因素，在脑刺激奖励（ICSS），并参与编码的一种类型的奖励预测NAc神经元和空间学习。
Predicting reward is essential in learning approach behaviors. Dopaminergic activity has been implicated in reward, movement, and cognitive processes, all essential elements in learning. The nucleus accumbens (NAc) receives converging inputs from corticolimbic information-processing areas and from mesolimbic dopamine neurons originating in the ventral tegmental area. Previously, we reported that in mice, a dopamine D2 receptor knockout (D2R-KO) eliminated the prereward inhibitory response, increased place-field size of NAc neurons, and reduced locomotor activity without marked change in intracranial self-stimulation (ICSS) behavior. The present study investigated the specific contribution of dopamine D1 receptor (D1R) in mediating reward, locomotor activity, and spatial associative processes and in regulating NAc neural responses. In contrast to D2R-KO animals, here we find D1R-KO in mice selectively eliminated the prereward excitatory response and decreased place-field size of NAc neurons. Furthermore, D1R-KO impaired ICSS behavior, seriously reduced locomotor activity, and retarded acquisition of a place learning task. Thus, the present results suggest that D1R may be an important determinant in brain stimulation reward (ICSS) and participates in coding for a type of reward prediction of NAc neurons and in spatial learning.