BETA-CARBOLINE ALKALOIDS .7. 1,9-DIMETALLATED BETA-CARBOLINES - VERSATILE BUILDING-BLOCKS FOR THE TOTAL SYNTHESIS OF ALKALOIDS
BETA-CARBOLINE ALKALOIDS .7. 1,9-DIMETALLATED BETA-CARBOLINES - VERSATILE BUILDING-BLOCKS FOR THE TOTAL SYNTHESIS OF ALKALOIDS
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DOI：
10.1016/s0040-4020(01)89542-9
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发表时间：
1994-10-24
期刊：
影响因子：
2.1
通讯作者：
HILDEBRAND, D
中科院分区：
文献类型：
--
作者：
BRACHER, F;HILDEBRAND, D
由1-溴-β-咔啉(4)制备的双金属β-咔啉6与亲电试剂反应是合成各种β-咔啉生物碱的关键步骤。6与氯化锌转金属，钯催化与2-氯代喹啉发生交叉偶联反应，得到生物碱硝基(14)。
Reactions of the dimetalated beta-carboline 6, prepared from 1-bromo-beta-carboline (4), with electrophiles are key steps in the syntheses of various beta-carboline alkaloids. Transmetalation of 6 with ZnCl2 followed by palladium-catalyzed cross coupling reaction with 2-chloxoquinoline gave the alkaloid nitramarine (14).