Prevalence and risk factors associated with the metabolic syndrome and dyslipidernia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela
Prevalence and risk factors associated with the metabolic syndrome and dyslipidernia in White, Black, Amerindian and Mixed Hispanics in Zulia State, Venezuela
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DOI：
10.1016/j.diabres.2004.11.018
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Goldberg, R
中科院分区：
文献类型：
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作者：
Florez, H;Silva, E;Goldberg, R
研究强调了胰岛素抵抗（IR）与几种心血管（CV）危险因素之间的关联，包括高血压（HTN）、肥胖、血脂异常（即高甘油三酯和低高密度脂蛋白胆固醇）和葡萄糖耐受不良，这些因素被称为代谢综合征（MS）。关于发展中国家多发性硬化症和血脂异常发生率的数据很少，南美洲也没有。为了估计委内瑞拉苏利亚州多发性硬化症及其组成部分的患病率，并确定相关的人口统计学和临床因素，我们从1999-2001年委内瑞拉苏利亚州每个卫生区随机抽样的代表性样本中评估了3108名20岁或以上的西班牙裔男性和女性。根据国家胆固醇教育计划(NCEP)/成人治疗小组III （ATP 111）标准定义多发性硬化症和血脂异常的患病率。经年龄调整的MS和血脂异常患病率分别为31.2%和24.1%，男性高于女性。患病率随着年龄和肥胖程度的增加而增加。与黑人（27.2%）、白人（33.3%）和混血儿（37.4%）相比，美洲印第安人（17.%）的多发性硬化症患病率较低，但在女性中没有发现差异。总体而言，低高密度脂蛋白胆固醇（65.3%）、腹部肥胖（42.9%）和HTN（38.1%）是MS最常见的成分。在调整了年龄、性别和种族后，糖尿病家族史、肥胖和HTN与多发性硬化症相关。久坐的生活方式也增加了多发性硬化症的风险，调整了相同协变量后的事件，肥胖和IR程度。这些结果表明，在委内瑞拉苏利亚州，大约三分之一的成年人口中发现了多发性硬化症，其中男性的患病率较高，与血脂异常的存在有关。委内瑞拉需要对MS受试者进行生活方式干预，以停止心血管疾病和糖尿病的负担。2005爱思唯尔爱尔兰有限公司版权所有。
Studies have highlighted the association between insulin resistance (IR) and several cardiovascular (CV) risk factors, including hypertension (HTN), obesity, dyslipidemia (i.e. high triglyceride and low HDL-cholesterol) and glucose intolerance, in a cluster known as the metabolic syndrome (MS). There are few data on the frequency of the MS and dyslipidemia in developing countries, and none in South America. To estimate the prevalence of the MS and its components in Zulia State, Venezuela, and to establish associated demographic and clinical factors, we evaluated 3108 Hispanic men and women aged 20 years or older from a cross-sectional survey of a random representative sample from each health district in Zulia State, Venezuela (1999-2001). Prevalence of the MS and dyslipidemia was defined according to the National Cholesterol Education Program (NCEP)/Adult Treatment Panel III (ATP 111) criteria. The age-adjusted prevalence of MS and dyslipidemia was 31.2% and 24.1%, respectively, with higher rates in men than in women. Prevalence rates increased with age and with the degree of obesity. MS prevalence was lower in Amerindian (17.%) compared to Black (27.2%), White (33.3%) and Mixed (37.4%) men, but no differences were found among women. Overall, low HDL-cholesterol (65.3%), abdominal obesity (42.9%) and HTN (38.1%) were the most frequent MS components. After adjusting for age, sex and race groups, family history of diabetes, obesity and HTN were associated with the MS. Sedentary lifestyle also increased the risk of MS, event after adjusting for the same covariates, obesity and the degree of IR. These results suggest that MS is found in approximately one-third of the Venezuelan adult population in Zulia State, with higher prevalence in men related to the presence of dyslipidemia. Lifestyle interventions in MS subjects are needed in Venezuela to halt the burden of CV disease and diabetes. (c) 2005 Elsevier Ireland Ltd. All rights reserved.