Hemisphere-specific effects of prefrontal theta-burst stimulation on visual recognition memory accuracy and awareness.
Hemisphere-specific effects of prefrontal theta-burst stimulation on visual recognition memory accuracy and awareness.
复制标题
前额叶θ爆发刺激对视觉识别记忆准确性和意识的半球特异性影响。
DOI：
10.1002/brb3.1228
复制
发表时间：
2019
影响因子：
3.1
通讯作者：
Ryals,AnthonyJ
中科院分区：
文献类型：
--
作者：
Carbajal,Ivan;O'Neil,JonathanT;Palumbo,RobertT;Voss,JoelL;Ryals,AnthonyJ
研究背景前额叶皮层与情景记忆和记忆意识有关。很少有研究通过脑刺激来探讨其作用的本质和必要性。关于刺激的半球是否预测对记忆的影响以及刺激的影响是否具有格式特异性，存在不确定性，大多数先前的研究利用言语/语义刺激。我们的主要目标是确定对前额皮质的θ脉冲经颅磁刺激（TBS）是否调节视觉记忆准确性，视觉记忆意识，或两者兼而有之。方法我们在三个不同的日子里，在左前额叶、右前额叶或假位置给12个个体施用TBS。然后，我们管理的视觉联想记忆任务，将全球水平的意识判断和感觉的认识（FOK）的判断，检索失败的测试trials for which retrieval failed.ResultsOverall memory accuracy显着提高后，右半球TBS相比，假。同时，受试者在右侧TBS后相对不自信，这表明对记忆准确性改善的意识最低。FOKs和后来的识别准确性之间的对应关系表明，在前瞻性记忆监测准确性中断后，左TBS.ConclusionsOur研究结果提供了独特的证据，改善视觉记忆准确性后，右前额叶TBS的模式。这些结果还表明，视觉记忆的右前额叶偏侧化和项目级前瞻性记忆意识判断的左半球专业化。总之，这些结果为无创刺激前额叶皮层作为一种潜在改善记忆和因果影响前瞻性记忆意识的手段提供了持续的支持。
BackgroundThe prefrontal cortex has been implicated in episodic memory and the awareness of memory. Few studies have probed the nature and necessity of its role via brain stimulation. There are uncertainties regarding whether the hemisphere of stimulation predicts effects on memory and whether effects of stimulation are format‐specific, with most previous studies utilizing verbal/semantic stimuli.ObjectiveOur primary objective was to determine if theta‐burst transcranial magnetic stimulation (TBS) to prefrontal cortex modulates visual memory accuracy, visual memory awareness, or both, and whether these effects depend on brain hemisphere.MethodsWe administered TBS to 12 individuals in either left prefrontal, right prefrontal, or a sham location on three separate days. We then administered a visual associative‐memory task incorporating global‐level awareness judgments and feeling‐of‐knowing (FOK) judgments on test trials for which retrieval failed.ResultsOverall memory accuracy significantly improved after right hemisphere TBS compared to sham. Simultaneously, subjects were relatively underconfident after right TBS, suggesting minimal awareness of memory accuracy improvements. The correspondence between FOKs and later recognition accuracy suggested a pattern of disruption in prospective memory monitoring accuracy after left TBS.ConclusionsOur findings provide unique evidence for improved visual memory accuracy after right prefrontal TBS. These results also suggest right prefrontal lateralization for visual memory and left‐hemisphere specialization for item‐level prospective memory awareness judgments. Taken together, these results provided continued support for noninvasive stimulation to prefrontal cortex as a means of potentially improving memory and causally influencing prospective memory awareness.