Mechanism for riboflavin enhancement of bilirubin photodecomposition in vitro.
Mechanism for riboflavin enhancement of bilirubin photodecomposition in vitro.
复制标题
核黄素增强体外胆红素光分解的机制。
DOI：
10.1002/jps.2600630319
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发表时间：
1974
影响因子：
3.8
通讯作者：
H. Kostenbauder
中科院分区：
文献类型：
--
作者：
D. Sanvordeker;H. Kostenbauder
在有氧条件下，核黄素可使胆红素的光解速率提高25倍。在没有氧气的情况下，无论有没有核黄素，胆红素的光解实际上都会停止。认为核黄素三重态物种产生的单线态氧是观察到的速率提高的主要原因。体内发生类似的光化学反应可能为通过全身给予适当的药物来提高胆红素光疗的效率提供一种手段。
Riboflavin increases the rate of bilirubin photodecomposition as much as 25-fold under aerobic conditions. In the absence of oxygen, bilirubin photodecomposition is virtually arrested, with or without riboflavin. It is proposed that singlet oxygen generated by the riboflavin triplet species is primarily responsible for the observed rate enhancement. The occurrence of similar photochemical reactions in vivo might provide a means for improving the efficiency of bilirubin phototherapy through systemic administration of appropriate agents.