Glioblastoma: Overview of Disease and Treatment.
Glioblastoma: Overview of Disease and Treatment.
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DOI：
10.1188/16.cjon.s1.2-8
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发表时间：
2016-10-01
影响因子：
1.1
通讯作者：
Davis ME
中科院分区：
文献类型：
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作者：
Davis ME
胶质母细胞瘤（GBM）是成人中最常见和最具侵袭性的恶性脑肿瘤。目前诊断时的治疗选择是多模式的，包括手术切除、放疗和化疗。对GBM分子病理学和相关细胞信号通路的理解的重大进展为复发性和新诊断疾病的新疗法开辟了机会。创新的治疗方法，如肿瘤治疗场（TTFields）和免疫疗法，为提高生存率带来了希望。本文综述了GBM的背景、风险、常见并发症和治疗选择。本文简要回顾了GBM，治疗方案，并介绍了已批准用于新发和复发性疾病的新疗法。尽管进行了积极的切除和综合方式的辅助治疗，大多数GBM复发。治疗，如TTFields，靶向分子受体的药物和免疫疗法，是有希望的新选择。
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Current treatment options at diagnosis are multimodal and include surgical resection, radiation, and chemotherapy. Significant advances in the understanding of the molecular pathology of GBM and associated cell signaling pathways have opened opportunities for new therapies for recurrent and newly diagnosed disease. Innovative treatments, such as tumor-treating fields (TTFields) and immunotherapy, give hope for enhanced survival. This article reviews the background, risks, common complications, and treatment options for GBM. A brief review of GBM, treatment options, and a look at new therapies that have been approved for new and recurrent disease are included in this article. Despite aggressive resection and combined modality adjuvant treatment, most GBMs recur. Treatments, such as TTFields, drugs to target molecular receptors, and immunotherapy, are promising new options.