Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study
Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study
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DOI：
10.1111/j.1471-0528.2010.02596.x
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发表时间：
2010-08-01
影响因子：
5.8
通讯作者：
Newnham, J. P.
中科院分区：
文献类型：
--
作者：
Robinson, M.;Oddy, W. H.;Newnham, J. P.
ObjectiveTo examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development.DesignThe Western Australian Pregnancy Cohort (Raine) Study recruited 2900 pregnancies (1989-91) and the 14-year follow up was conducted between 2003 and 2006.SettingTertiary obstetric hospital in Perth, Western Australia.PopulationThe women in the study provided data at 18 and 34 weeks of gestation on weekly alcohol intake: no drinking, occasional drinking (up to one standard drink per week), light drinking (2-6 standard drinks per week), moderate drinking (7-10 standard drinks per week), and heavy drinking (11 or more standard drinks per week).MethodsLongitudinal regression models were used to analyse the effect of prenatal alcohol exposure on Child Behaviour Checklist (CBCL) scores over 14 years, assessed by continuous z-scores and clinical cutoff points, after adjusting for confounders.Main outcome measureTheir children were followed up at ages 2, 5, 8, 10 and 14 years. The CBCL was used to measure child behaviour.ResultsLight drinking and moderate drinking in the first 3 months of pregnancy were associated with child CBCL z-scores indicative of positive behaviour over 14 years after adjusting for maternal and sociodemographic characteristics. These changes in z-score indicated a clinically meaningful reduction in total, internalising and externalising behavioural problems across the 14 years of follow up.ConclusionsOur findings do not implicate light-moderate consumption of alcohol in pregnancy as a risk factor in the epidemiology of child behavioural problems.
