Hybrid Bionanoparticle-Stabilized Pickering Emulsions for Quercetin Delivery: Effect of Interfacial Composition on Release, Lipolysis, and Bioaccessibility
Hybrid Bionanoparticle-Stabilized Pickering Emulsions for Quercetin Delivery: Effect of Interfacial Composition on Release, Lipolysis, and Bioaccessibility
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用于槲皮素递送的混合生物纳米颗粒稳定的 Pickering 乳液：界面组成对释放、脂肪分解和生物可及性的影响
DOI：
10.1021/acsanm.9b01413
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发表时间：
2019-10-01
影响因子：
5.9
通讯作者：
Liu, Wei
中科院分区：
文献类型：
--
作者：
Chen, Xing;Chen, Yan;Liu, Wei
采用两阶段方法组装由麦醇溶蛋白/磷脂纳米颗粒稳定的皮克林乳液：（i）通过高速剪切形成含有大油滴（d = 4.0至40 μ m）的粗乳液;（ii）然后通过使用微流化分解大液滴产生含有小液滴（d = 0.71至1.1 μ m）的细乳液。所得乳液含有纳米颗粒涂覆的油滴，其抵抗重力分离。乳液的界面弹性和包封率随着界面磷脂含量的增加而增加。相反，增加界面磷脂水平抑制脂质消化，这可能是因为磷脂诱导液滴聚结在胃中，这降低了油-水界面面积的脂肪酶。最后，较高的界面磷脂水平减少了化学降解，提高了槲皮素的生物可及性，这可能会提高其生物活性。
Pickering emulsions stabilized by gliadin/phospholipid nanoparticles were assembled employing a two-stage method: (i) coarse emulsions containing large oil droplets (d = 4.0 to 40 mu m) were formed by high-speed shearing; (ii) fine emulsions containing small droplets (d = 0.71 to 1.1 mu m) were then created by breaking down the large droplets using microfluidization. The resultant emulsions contained nanoparticle-coated oil droplets that were resistant to gravitational separation. The interfacial elasticity and encapsulation efficiency of the emulsions increased as the interfacial phospholipid level was increased. Conversely, increasing the interfacial phospholipid level inhibited lipid digestion, which was presumably because the phospholipids induced droplet coalescence in the stomach, which decreased the oil-water interfacial area accessible to the lipase. Finally, a higher interfacial phospholipid level reduced the chemical degradation and enhanced the bioaccessibility of quercetin, which may improve its bioactivity.