An experimental design for the development of adaptive treatment strategies
An experimental design for the development of adaptive treatment strategies
复制标题
DOI：
10.1002/sim.2022
复制
发表时间：
2005-05-30
影响因子：
2
通讯作者：
Murphy, SA
中科院分区：
文献类型：
--
作者：
Murphy, SA
在适应性治疗策略中，治疗水平和类型根据正在进行的个体反应反复调整。由于过去的治疗可能有延迟效应，这些治疗策略的发展具有挑战性。本文主张在适应性治疗策略的发展中使用序贯多重分配随机试验。既提供了一个简单的ad hoe方法来确定样本大小和简单的分析方法。版权所有（c）2004年约翰威利父子有限公司。
In adaptive treatment strategies, the treatment level and type is repeatedly adjusted according to ongoing individual response. Since past treatment may have delayed effects, the development of these treatment strategies is challenging. This paper advocates the use of sequential multiple assignment randomized trials in the development of adaptive treatment strategies. Both a simple ad hoe method for ascertaining sample sizes and simple analysis methods are provided. Copyright (c) 2004 John Wiley & Sons, Ltd.